通过门控99mTc-MIBI单光子发射计算机断层显像（SPECT）定量测定左心室容积和射血分数：EXINI心脏软件包的磁共振成像（MRI）验证
Quantification of left ventricular volumes and ejection fraction from gated 99mTc-MIBI SPECT: MRI validation of the EXINI heart software package.
作者信息
Winz Oliver H, Meyer Philipp T, Knollmann Daniela, Lipke Claudia S A, Kühl Harald P, Oelve Carola, Schaefer Wolfgang M
机构信息
Department of Nuclear Medicine, University Hospital, Aachen University of Technology, Aachen, Germany.
出版信息
Clin Physiol Funct Imaging. 2009 Apr;29(2):89-94. doi: 10.1111/j.1475-097X.2008.00840.x. Epub 2008 Dec 5.
UNLABELLED
The aim of the study was to validate the accuracy of the EXINI heart software (EXINI) package in assessing left ventricular end-diastolic/systolic volumes (EDV, ESV) and ejection fraction (LVEF) from gated (99m)Tc-MIBI single-photon emission tomography (SPECT). Cardiac magnetic resonance imaging (cMRI) was used as reference. Furthermore, effects of perfusion defects and image quality in SPECT on correlation between gated SPECT and magnetic resonance imaging were investigated.
METHODS
Seventy patients were examined using gated SPECT (rest study, eight gates per cardiac cycle). EDV, ESV and LVEF were calculated from gated SPECT using EXINI. Directly before or after SPECT, cMRI (20 gates cardiac per cycle) was performed. EDV, ESV and LVEF were calculated using Simpson's rule. Perfusion defects were quantified using the summed-rest-score (SRS). Total number of myocardial counts were used to rate image quality.
RESULTS
Correlation between results of gated SPECT and cMRI was high for EDV (R = 0.89) and ESV (R = 0.94) and good for LVEF (R = 0.78). ESV (EXINI 54 +/- 31 ml versus cMRI 57 +/- 34 ml) and LVEF (EXINI 62.9 +/- 11.7% versus cMRI 60.6 +/- 13.9%) did not differ significantly whereas EXINI overestimated EDV significantly compared with cMRI (EXINI 144 +/- 41 ml versus cMRI 137 +/- 36 ml; P<0.005). No correlation was found between absolute differences of the results given by gated SPECT and cMRI and SRS or total myocardial counts (R < 0.18).
CONCLUSION
End-diastolic volume, ESV and LVEF calculated from gated SPECT using EXINI agree with cMRI over a wide range of values. Correlation between both the methods was good for EDV and ESV, and acceptable for LVEF. No relevant influence of image quality or SRS on the accuracy of EXINI results was found.
未标注
本研究的目的是验证EXINI心脏软件（EXINI）包在通过门控（99m）锝-甲氧基异丁基异腈单光子发射断层扫描（SPECT）评估左心室舒张末期/收缩末期容积（EDV、ESV）和射血分数（LVEF）方面的准确性。心脏磁共振成像（cMRI）用作参考。此外，还研究了SPECT中的灌注缺损和图像质量对门控SPECT与磁共振成像之间相关性的影响。
方法
对70例患者进行门控SPECT检查（静息研究，每个心动周期8个门控）。使用EXINI从门控SPECT计算EDV、ESV和LVEF。在SPECT检查之前或之后立即进行cMRI（每个心动周期20个心脏门控）。使用Simpson法则计算EDV、ESV和LVEF。使用静息总积分（SRS）对灌注缺损进行量化。使用心肌计数总数对图像质量进行评分。
结果
门控SPECT与cMRI结果之间的相关性对于EDV较高（R = 0.89），对于ESV较高（R = 0.94），对于LVEF良好（R = 0.78）。ESV（EXINI为54±31 ml，cMRI为57±34 ml）和LVEF（EXINI为62.9±11.7%，cMRI为60.6±13.9%）无显著差异，而与cMRI相比，EXINI显著高估了EDV（EXINI为144±41 ml，cMRI为137±36 ml；P<0.005）。门控SPECT和cMRI给出的结果的绝对差异与SRS或心肌计数总数之间未发现相关性（R<0.18）。
结论
使用EXINI从门控SPECT计算的舒张末期容积、ESV和LVEF在很宽的值范围内与cMRI一致。两种方法之间的相关性对于EDV和ESV良好，对于LVEF可接受。未发现图像质量或SRS对EXINI结果准确性有相关影响。
Zotero 插件