Gal'perin E I, Tatishvili G G, Akhaladze G G, Sakevarashvili G R, Nasirov F N, Aref'ev A E
Khirurgiia (Mosk). 1991 Sep(9):77-81.
The blood flow in the portal vein and hepatic artery was studied by means of ultrasonic Doppler flow measurement to investigate organic and regional hemodynamics of the liver in purulent cholangitis. The blood flow in the portal vein was found to be significantly diminished in patients with acute cholangitis and hepatic failure. Hepatic microcirculation was studied on a experimental model of obstructive jaundice and obstructive purulent cholangitis in rats by polarographic measurement of hydrogen clearance. Considerable reduction of the volume rate of the local blood flow was noted, and the degree of the reduction was related to the severity and duration of the disease. Decompression of the biliary tract by external drainage improved the local blood flow rate which, however, diminished again in prolonged external drainage. The use of pharmacological agents for correction of microcirculation in decompression of the biliary tract led to total and rapid correction of the volume rate of the local blood flow.
采用超声多普勒血流测量法研究门静脉和肝动脉的血流情况，以探讨化脓性胆管炎时肝脏的器官和局部血流动力学。发现急性胆管炎和肝衰竭患者的门静脉血流显著减少。通过极谱法测量氢气清除率，在大鼠梗阻性黄疸和梗阻性化脓性胆管炎实验模型上研究肝微循环。观察到局部血流容积率显著降低，且降低程度与疾病的严重程度和持续时间有关。通过外部引流进行胆道减压可改善局部血流速率，但在长期外部引流时血流速率又会再次降低。在胆道减压中使用药理药物纠正微循环可使局部血流容积率完全且迅速得到纠正。
