Wasfy M O, Moustafa D A, El-Gendy A M, Mohran Z S, Ismail T F, El-Etr S H, Oyofo B A
Research Sciences Department, U.S. Naval Medical Research Unit No. 3, Cairo, Egypt.
J Egypt Public Health Assoc. 1996;71(1-2):149-60.
This report describes the resistance of 537 Salmonella typhi isolates identified in Egypt between 1990-1994. Results indicated a high isolation rate for multiple resistant S. typhi (> 71% of isolates collected in 1992-93), particularly to the three standard drug regimens of the clinically relevant antibiotics; ampicillin, chloramphenicol and trimethoprim-sulfamethoxazole. This adds to the complexity and difficulty of treating infections caused by these organisms. Resistance of S. typhi was associated with a transferable 120 MD plasmid. The organism was sensitive to amikacin, aztreonam, cephalothin, ceftriaxone, gentamicin and nalidixic acid, suggesting the use of aztreonam and ceftriaxone as alternative therapeutic drugs for the treatment of multidrug-resistant S. typhi. These results may provide a clinically useful evaluation of the spread and acquisition of resistance among S. typhi strains in Egypt.
本报告描述了1990 - 1994年在埃及鉴定出的537株伤寒沙门氏菌的耐药情况。结果表明多重耐药伤寒沙门氏菌的分离率很高（1992 - 1993年收集的分离株中>71%），尤其是对临床相关抗生素的三种标准药物治疗方案；氨苄青霉素、氯霉素和甲氧苄啶 - 磺胺甲恶唑。这增加了治疗由这些微生物引起的感染的复杂性和难度。伤寒沙门氏菌的耐药性与一种可转移的120 MD质粒有关。该微生物对阿米卡星、氨曲南、头孢噻吩、头孢曲松、庆大霉素和萘啶酸敏感，提示氨曲南和头孢曲松可作为治疗多重耐药伤寒沙门氏菌的替代治疗药物。这些结果可能为埃及伤寒沙门氏菌菌株耐药性的传播和获得情况提供临床有用的评估。
