Voets T, Owsianik G, Nilius B
Laboratory of Physiology, KU Leuven, Campus Gasthuisberg O and N, 3000 Leuven, Belgium.
Handb Exp Pharmacol. 2007(179):329-44. doi: 10.1007/978-3-540-34891-7_20.
Originally cloned as a prostate-specific protein, TRPM8 is now best known as a cold- and menthol-activated channel implicated in thermosensation. In this chapter we provide a brief review of current knowledge concerning the biophysical properties, gating mechanisms, pharmacology and (patho)physiology of this TRP channel.
TRPM8最初作为一种前列腺特异性蛋白被克隆，现在最为人所知的是它作为一种与冷觉感受有关的、可被寒冷和薄荷醇激活的通道。在本章中，我们简要回顾一下关于这个瞬时受体电位（TRP）通道的生物物理特性、门控机制、药理学及（病理）生理学的现有知识。
