Culić Viktor
Odjel za kardiologiju, Klinika za unutarnje bolesti, Klinicka bolnica Split, Split, Hrvatska.
Acta Med Croatica. 2006 Dec;60(5):439-45.
Acute coronary syndrome (ACS) is an important entity of the cardiovascular morbidity and mortality. Everyday circumstances which significantly increase the risk of the onset of ACS during the period of several hours have been termed acute risk factors. This term includes morning hours and various possible external triggers such as heavy physical exertion, emotional stress, sexual activity, meteorological stress, and large meals. Possible external triggers precede approximately a half of the onsets of ACS, more frequently in men. Conversely, emotional stress plays a more important role in the triggering of ACS in women. Circadian rhythm represents an independent natural pattern of endogenous functions which is responsible for the morning excess in the incidence of ACS. A beneficial effect of regular physical activity and use of beta-blocker, calcium antagonists, nitrates and aspirin in the prevention of triggering ACS by acute risk factors has been described. Identification of further acute risk factors and better understanding of internal triggering mechanisms may improve the prevention of ACS and other cardiovascular incidents.
急性冠状动脉综合征（ACS）是心血管疾病发病和死亡的一个重要类型。在数小时内显著增加ACS发病风险的日常情况被称为急性危险因素。这个术语包括早晨时段以及各种可能的外部触发因素，如剧烈体力活动、情绪应激、性活动、气象应激和大餐。大约一半的ACS发病之前存在可能的外部触发因素，在男性中更为常见。相反，情绪应激在女性ACS的触发中起更重要的作用。昼夜节律代表内源性功能的一种独立自然模式，它导致了ACS发病率在早晨的增加。规律的体育活动以及使用β受体阻滞剂、钙拮抗剂、硝酸盐和阿司匹林在预防急性危险因素触发ACS方面的有益作用已被描述。识别更多的急性危险因素并更好地理解内部触发机制可能会改善ACS和其他心血管事件的预防。
