Brosman S A, Tokita K
Department of Surgery/Urology, St. John's Hospital and Health Center, Santa Monica, California.
Urology. 1991 Oct;38(4):372-6. doi: 10.1016/0090-4295(91)80157-3.
The use of interstitial implants for the treatment of low-stage prostate cancer using transrectal ultrasound guidance is evaluated in 80 patients. This outpatient procedure involves the placement of needles through a template and into the prostate. Ultrasound guidance is used to place the needles into a preselected location. The needles are loaded with a radioactive source. In this study Palladium-103 was utilized. This technique allows accurate and complete seeding of the prostate. There was a 50 percent or greater decrease in prostate size in all of the patients who were implanted. Prostate-specific antigen (PSA) levels became normal or decreased by more than 50 percent in 97 percent of the patients. Most patients experienced urethral irritative symptoms which lasted up to five months, but none of the patients experienced rectal symptoms lasting longer than a month. The mean follow-up is 11.8 months which is too brief to ascertain the effectiveness of this therapy. The method appears to be safe and may represent an alternative to external beam irradiation.
对80例患者评估了经直肠超声引导下间质植入物治疗低分期前列腺癌的效果。这种门诊手术包括通过模板将针插入前列腺。超声引导用于将针放置在预选位置。针内装有放射性源。在本研究中使用的是钯-103。该技术可实现前列腺的准确和完全植入。所有植入患者的前列腺体积均减少了50%或更多。97%的患者前列腺特异性抗原（PSA）水平恢复正常或下降超过50%。大多数患者出现尿道刺激症状，持续长达5个月，但无一例患者出现持续超过1个月的直肠症状。平均随访时间为11.8个月，时间过短，无法确定该疗法的有效性。该方法似乎是安全的，可能是外照射的一种替代方法。
