Paris Pamela L, Hofer Matthias D, Albo Giancarlo, Kuefer Rainer, Gschwend Juergen E, Hautmann Richard E, Fridyland Jane, Simko Jeffrey, Carroll Peter R, Rubin Mark A, Collins Colin
Department of Urology, University of California at San Francisco Comprehensive Cancer Center, San Francisco, CA 94115, USA.
Neoplasia. 2006 Dec;8(12):1083-9. doi: 10.1593/neo.06421.
The progression of organ-confined prostate cancer to metastatic cancer is inevitably fatal. Consequently, identification of structural changes in the genome and associated transcriptional responses that drive this progression is critical to understanding the disease process and the development of biomarkers and therapeutic targets. In this study, whole genome copy number changes in genomes of hormone-naïve lymph node metastases were profiled using array comparative genomic hybridization, and matched primaries were included for a subset. Matched primaries and lymph node metastases showed very similar copy number profiles that are distinct from primary tumors that fail to metastasize.
局限于器官的前列腺癌进展为转移性癌症必然是致命的。因此,识别驱动这种进展的基因组结构变化及相关转录反应对于理解疾病过程以及生物标志物和治疗靶点的开发至关重要。在本研究中,使用阵列比较基因组杂交分析了未接受激素治疗的淋巴结转移瘤基因组中的全基因组拷贝数变化,并纳入了一部分匹配的原发肿瘤。匹配的原发肿瘤和淋巴结转移瘤显示出非常相似的拷贝数谱,这与未发生转移的原发肿瘤不同。