Kyo M, Mihatsch M J
Department of Urology, Hyogo Prefectural Nishinomiya Hospital.
Hinyokika Kiyo. 1991 Oct;37(10):1153-8.
To make the differentiation of kidney transplant acute rejection and ciclosporin (CS) nephrotoxicity urine cytology by classical Papanicolaou with immunocytochemical stain has been performed. Increased numbers of renal tubular cells with lymphocytes and monocytes were found in both rejections and CS toxicities. CS toxicities were associated with increased numbers of proximal tubular cells. In immunocytochemical stain, increased numbers of CD25 and CD8 positive cells as well as increased ratio of HLA-DR/cytokeratin positive cells were typically found in rejections. It is concluded that the proposed analysis of urine cytology is a non-invasive and reliable method for daily graft monitoring of acute rejection and CS toxicity.
为了通过经典巴氏染色结合免疫细胞化学染色来鉴别肾移植急性排斥反应和环孢素（CS）肾毒性，已进行了尿液细胞学检查。在排斥反应和CS毒性中均发现肾小管细胞与淋巴细胞和单核细胞数量增加。CS毒性与近端肾小管细胞数量增加有关。在免疫细胞化学染色中，排斥反应中通常发现CD25和CD8阳性细胞数量增加以及HLA-DR/细胞角蛋白阳性细胞比例增加。结论是，所提出的尿液细胞学分析是一种用于急性排斥反应和CS毒性日常移植物监测的非侵入性且可靠的方法。
