II型高脂蛋白血症中3-羟基-3-甲基戊二酰辅酶A还原酶活性的调节
Regulation of 3-hydroxy-3-methylglutaryl coenzyme-A reductase activity in type II hyperlipoproteinaemia.
作者信息
Betteridge D J, Higgins M J, Galton D J
出版信息
Br Med J. 1975 Nov 29;4(5995):500-2. doi: 10.1136/bmj.4.5995.500.
Abstract
The regulation of 3-hydroxy-3-methylglutaryl coenzyme-A reductase activity in leucocytes was studied in a family with familial type II hyperlipoproteinaemia (WHO classification). The propositus was heterozygous and 16 other members of the family were studied. Leucocytes were isolated by a relatively quick and simple procedure and used for enzyme estimations. The results suggest that measurement of the regulation of this enzyme in leucocytes may be helpful in the diagnosis and management of the condition.
摘要
在一个患有家族性II型高脂蛋白血症（世界卫生组织分类）的家族中，研究了白细胞中3-羟基-3-甲基戊二酰辅酶A还原酶活性的调节。先证者为杂合子，并对该家族的其他16名成员进行了研究。通过一种相对快速且简单的程序分离白细胞，并用于酶的测定。结果表明，测量白细胞中这种酶的调节可能有助于该疾病的诊断和管理。
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