• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

II型高脂蛋白血症中3-羟基-3-甲基戊二酰辅酶A还原酶活性的调节

Regulation of 3-hydroxy-3-methylglutaryl coenzyme-A reductase activity in type II hyperlipoproteinaemia.

作者信息

Betteridge D J, Higgins M J, Galton D J

出版信息

Br Med J. 1975 Nov 29;4(5995):500-2. doi: 10.1136/bmj.4.5995.500.

DOI:10.1136/bmj.4.5995.500
PMID:172188
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1675613/
Abstract

The regulation of 3-hydroxy-3-methylglutaryl coenzyme-A reductase activity in leucocytes was studied in a family with familial type II hyperlipoproteinaemia (WHO classification). The propositus was heterozygous and 16 other members of the family were studied. Leucocytes were isolated by a relatively quick and simple procedure and used for enzyme estimations. The results suggest that measurement of the regulation of this enzyme in leucocytes may be helpful in the diagnosis and management of the condition.

摘要

在一个患有家族性II型高脂蛋白血症（世界卫生组织分类）的家族中，研究了白细胞中3-羟基-3-甲基戊二酰辅酶A还原酶活性的调节。先证者为杂合子，并对该家族的其他16名成员进行了研究。通过一种相对快速且简单的程序分离白细胞，并用于酶的测定。结果表明，测量白细胞中这种酶的调节可能有助于该疾病的诊断和管理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87c2/1675613/e167c31a74fd/brmedj01476-0024-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87c2/1675613/e167c31a74fd/brmedj01476-0024-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87c2/1675613/e167c31a74fd/brmedj01476-0024-a.jpg

相似文献

1
Regulation of 3-hydroxy-3-methylglutaryl coenzyme-A reductase activity in type II hyperlipoproteinaemia.II型高脂蛋白血症中3-羟基-3-甲基戊二酰辅酶A还原酶活性的调节
Br Med J. 1975 Nov 29;4(5995):500-2. doi: 10.1136/bmj.4.5995.500.
2
A new type of familial hypercholesterolaemia.
Lancet. 1975 Oct 18;2(7938):737-40. doi: 10.1016/s0140-6736(75)90723-0.
3
Regulation of cholesterol synthesis in the hyperlipoproteinaemias. Polymorphonuclear leucocyte abnormality specific to familial type II hypercholesterolaemia.高脂血症中胆固醇合成的调节。家族性II型高胆固醇血症特有的多形核白细胞异常。
Atherosclerosis. 1978 Mar;29(3):291-9. doi: 10.1016/0021-9150(78)90077-1.
4
In vivo regulation of human mononuclear leukocyte 3-hydroxy-3-methylglutaryl coenzyme A reductase. Decreased enzyme catalytic efficiency in familial hypercholesterolemia.人单核白细胞3-羟基-3-甲基戊二酰辅酶A还原酶的体内调节。家族性高胆固醇血症中酶催化效率降低。
J Clin Invest. 1987 Nov;80(5):1401-8. doi: 10.1172/JCI113218.
5
Diagnosing familial hypercholesterolaemia in childhood.儿童家族性高胆固醇血症的诊断
Br Med J. 1977 Jul 9;2(6079):127. doi: 10.1136/bmj.2.6079.127-a.
6
Control of 3-hydroxy-3-methylglutaryl-CoA reductase activity in cultured human fibroblasts by very low density lipoproteins of subjects with hypertriglyceridemia.高甘油三酯血症患者极低密度脂蛋白对培养的人成纤维细胞中3-羟基-3-甲基戊二酰辅酶A还原酶活性的调控
J Clin Invest. 1978 Feb;61(2):320-8. doi: 10.1172/JCI108942.
7
Mechanism of induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase in human leukocytes.
J Biol Chem. 1977 Jan 25;252(2):644-51.
8
Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol.家族性高胆固醇血症：与胆固醇过度产生相关的3-羟基-3-甲基戊二酰辅酶A还原酶活性调节缺陷的鉴定。
Proc Natl Acad Sci U S A. 1973 Oct;70(10):2804-8. doi: 10.1073/pnas.70.10.2804.
9
[Crystalline corneal dystrophy (Schnyder) in the presence of familial type IIa hyperlipoproteinaemia (author's transl)].家族性IIa型高脂蛋白血症伴结晶状角膜营养不良（施奈德型）（作者译）
Klin Monbl Augenheilkd. 1977 Nov;171(5):678-84.
10
Mechanism of regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity by low density lipoprotein in human lymphocytes.低密度脂蛋白对人淋巴细胞中3-羟基-3-甲基戊二酰辅酶A还原酶活性的调节机制
Eur J Clin Invest. 1979 Oct;9(5):405-10. doi: 10.1111/j.1365-2362.1979.tb00904.x.

引用本文的文献

1
Diagnosing familial hypercholesterolaemia in childhood.儿童家族性高胆固醇血症的诊断
Br Med J. 1977 Aug 13;2(6084):455-6. doi: 10.1136/bmj.2.6084.455-c.
2
Diagnosing familial hypercholesterolaemia in childhood.儿童家族性高胆固醇血症的诊断
Br Med J. 1977 Jul 9;2(6079):127. doi: 10.1136/bmj.2.6079.127-a.
3
Diagnosing familial hypercholesterolaemia in childhood.儿童家族性高胆固醇血症的诊断

本文引用的文献

1
SEPARATION OF VIABLE LYMPHOCYTES FROM HUMAN BLOOD.从人血中分离活淋巴细胞
Lancet. 1964 Feb 29;1(7331):468-9. doi: 10.1016/s0140-6736(64)90799-8.
2
Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol.家族性高胆固醇血症：与胆固醇过度产生相关的3-羟基-3-甲基戊二酰辅酶A还原酶活性调节缺陷的鉴定。
Proc Natl Acad Sci U S A. 1973 Oct;70(10):2804-8. doi: 10.1073/pnas.70.10.2804.
3
Simplified spectrophotometric assay for microsomal 3-hydroxy-3-methylglutaryl CoA reductase by measurement of coenzyme A.
Br Med J. 1977 Oct 29;2(6095):1156. doi: 10.1136/bmj.2.6095.1156.
4
Properties of sterol biosynthesis in human leukocytes: effects of gemfibrozil.人白细胞中甾醇生物合成的特性：吉非贝齐的作用
Proc R Soc Med. 1976;69 Suppl 2(Suppl 2):104-6. doi: 10.1177/00359157760690S227.
通过测定辅酶A对微粒体3-羟基-3-甲基戊二酰辅酶A还原酶进行简化的分光光度测定法。
J Lipid Res. 1973 Nov;14(6):625-31.
4
Abnormal induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase in leukocytes from subjects with heterozygous familial hypercholesterolemia.杂合子家族性高胆固醇血症患者白细胞中3-羟基-3-甲基戊二酰辅酶A还原酶的异常诱导。
J Biol Chem. 1975 Mar 25;250(6):2045-55.