99m锝-二乙三胺五乙酸在肺结节病中的清除率

Clearance of technetium-99m-DTPA in pulmonary sarcoidosis.

作者信息

Antoniou K M, Tzanakis N, Malagari K, Symvoulakis K E, Perisinakis K, Karkavitsas N, Siafakas N M, Bouros D E

机构信息

Thoracic Medicine, Medical School University of Crete, Heraklion.

出版信息

Monaldi Arch Chest Dis. 2006 Sep;65(3):141-4. doi: 10.4081/monaldi.2006.559.

DOI:10.4081/monaldi.2006.559

PMID:17220103

Abstract

BACKGROUND

The aim of this study was to explore the possible association of the lung clearance of 99mTc-DTPA scan with HRCT lung abnormalities and with the pulmonary function tests [PFTs] in patients with sarcoidosis.

METHODS

We studied prospectively 15 patients [5 males, 10 females] of median age 46yr [range 27-67] with histologically proved sarcoidosis. HRCT scoring included the sum of the severity and extent of lymph node enlargement and parenchymal involvement.

RESULTS

The mean DTPA clearance half-time [tau 1/ <40 min] was found [mean [SD]] 38.3+/-4.5min. The lymph node enlargement was found 34% and the parenchymal involvement 12%. DTPA clearance was negatively correlated with the parenchymal involvement [r= -0.651, p=0.0091]. The HRCT parenchymal abnormalities were found significantly correlated with PFTs [FVC [r= -0.65, p=0.008] and TLCO [r= -0.76, p=0.02].

CONCLUSIONS

Our data suggest a moderate association between 99mTc-DTPA scan and HRCT in pulmonary sarcoidosis. However, further studies in large scale of sarcoid patients are needed to clarify the role of this novel methodology in the evaluation and follow-up of this disorder.

摘要

背景

本研究旨在探讨结节病患者99mTc-DTPA扫描的肺清除率与高分辨率CT（HRCT）肺部异常及肺功能测试（PFTs）之间可能存在的关联。

方法

我们前瞻性地研究了15例经组织学证实为结节病的患者（5例男性，10例女性），中位年龄46岁（范围27 - 67岁）。HRCT评分包括淋巴结肿大和实质受累的严重程度及范围之和。

结果

发现DTPA清除半衰期（tau 1/ <40分钟）平均（标准差）为38.3±4.5分钟。发现淋巴结肿大率为34%，实质受累率为12%。DTPA清除率与实质受累呈负相关（r = -0.651，p = 0.0091）。HRCT实质异常与PFTs显著相关（用力肺活量（FVC）（r = -0.65，p = 0.008）和一氧化碳弥散量（TLCO）（r = -0.76，p = 0.02））。