Xhaard Aliénor, Robin Marie, Scieux Catherine, de Latour Régis Peffault, Deplus Sylvie, Mazeron Marie-Christine, Devergie Agnès, Espérou Hélène, Rocha Vanderson, Gluckman Eliane, Ribaud Patricia, Socié Gérard
Service d'Hématologie-Transplantation, Hôpital Saint-Louis, Paris, France.
Transplantation. 2007 Jan 15;83(1):80-3. doi: 10.1097/01.tp.0000239512.94181.e9.
Six cases of cytomegalovirus retinitis (CMVR) after allogeneic hematopoietic stem cell transplantation were diagnosed between 2002 and 2005 in our center, whereas only one case was diagnosed between 1985 and 2001. Cumulative incidence reaches 2.2%, whereas this complication has been rarely described after hematopoietic stem cell transplantation. We aimed to describe clinical and biologic features of CMVR and search for risk factors associated with CMVR. CMVR was diagnosed on specific funduscopic examination in all patients either on visual symptoms (n=3) or on systematic ophthalmologic examination (n=3). CMVR occurred in the context of unrelated transplantation in patients with profound immune defect and multiple episodes of cytomegalovirus (CMV) reactivation. The combination of a CMV-seropositive recipient and CMV-seronegative donor was the leading risk factor.
2002年至2005年期间，我院诊断出6例异基因造血干细胞移植后巨细胞病毒性视网膜炎（CMVR），而1985年至2001年期间仅诊断出1例。累积发病率达2.2%，而造血干细胞移植后这种并发症鲜有报道。我们旨在描述CMVR的临床和生物学特征，并寻找与CMVR相关的危险因素。所有患者均通过特定的眼底检查诊断出CMVR，其中3例因视觉症状确诊，3例经系统眼科检查确诊。CMVR发生在免疫严重缺陷且巨细胞病毒（CMV）多次激活的非亲缘移植患者中。CMV血清学阳性受者与CMV血清学阴性供者的组合是主要危险因素。
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