健康与疾病中的活性糖转运

Active sugar transport in health and disease.

作者信息

Wright E M, Hirayama B A, Loo D F

机构信息

Department of Physiology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1751, USA.

出版信息

J Intern Med. 2007 Jan;261(1):32-43. doi: 10.1111/j.1365-2796.2006.01746.x.

DOI:10.1111/j.1365-2796.2006.01746.x

PMID:17222166

Abstract

Secondary active glucose transport occurs by at least four members of the SLC5 gene family. This review considers the structure and function of two premier members, SGLT1 and SGLT2, and their role in intestinal glucose absorption and renal glucose reabsorption. Genetics disorders of SGLTs include Glucose-Galactose Malabsorption, and Familial Renal Glucosuria. SGLT1 plays a central role in Oral Rehydration Therapy used so effectively to treat secretory diarrhoea such as cholera. Increasing attention is being focused on SGLTs as drug targets for the therapy of diabetes.

摘要

继发性主动葡萄糖转运至少由SLC5基因家族的四个成员介导。本综述探讨了两个主要成员SGLT1和SGLT2的结构与功能，以及它们在肠道葡萄糖吸收和肾脏葡萄糖重吸收中的作用。SGLT的遗传性疾病包括葡萄糖-半乳糖吸收不良和家族性肾性糖尿。SGLT1在口服补液疗法中发挥核心作用，该疗法可有效治疗霍乱等分泌性腹泻。人们越来越关注将SGLT作为糖尿病治疗的药物靶点。