用于皮肤给药的脂质囊泡：三十年研究综述

Lipid vesicles for skin delivery of drugs: reviewing three decades of research.

作者信息

Elsayed Mustafa M A, Abdallah Ossama Y, Naggar Viviane F, Khalafallah Nawal M

机构信息

Department of Pharmaceutics, Faculty of Pharmacy, University of Alexandria, El-Khartoum Square, El-Azarita, Alexandria 21521, Egypt.

出版信息

Int J Pharm. 2007 Mar 6;332(1-2):1-16. doi: 10.1016/j.ijpharm.2006.12.005. Epub 2006 Dec 8.

DOI:10.1016/j.ijpharm.2006.12.005

PMID:17222523

Abstract

Since liposomes were first shown to be of potential value for topical therapy by Mezei and Gulasekharam in 1980, studies continued towards further investigation and development of lipid vesicles as carriers for skin delivery of drugs. Despite this long history of intensive research, lipid vesicles are still considered as a controversial class of dermal and transdermal carriers. Accordingly, this article provides an overview of the development of lipid vesicles for skin delivery of drugs, with special emphasis on recent advances in this field, including the development of deformable liposomes and ethosomes.

摘要

自1980年Mezei和Gulasekharam首次证明脂质体在局部治疗中具有潜在价值以来，人们持续开展研究，进一步探索和开发脂质囊泡作为药物经皮递送的载体。尽管有这段长期深入研究的历史，但脂质囊泡仍被视为一类存在争议的真皮和透皮载体。因此，本文概述了用于药物经皮递送的脂质囊泡的发展情况，特别强调了该领域的最新进展，包括可变形脂质体和醇质体的发展。