Peng Xueli, Ma Yuning, Yan Chenxin, Wei Xiaocen, Zhang Linlin, Jiang Hehe, Ma Yuxia, Zhang Suohui, Xing Mengzhen, Gao Yunhua
Qingdao Academy of Chinese Medical Sciences, Shandong University of Traditional Chinese Medicine, Qingdao 266112, China.
Key Laboratory of New Material Research Institute, Institute of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
Pharmaceutics. 2024 Aug 1;16(8):1022. doi: 10.3390/pharmaceutics16081022.
Skin pigmentation typically arises from the excessive secretion and accumulation of melanin, resulting in a darker complexion compared to normal skin. Currently, the local application of chemical drugs is a first-line strategy for pigmentation disorders, but the safety and efficacy of drugs still cannot meet clinical treatment needs. For long-term and safe medication, researchers have paid attention to natural products with higher biocompatibility. This article begins by examining the pathogenesis and treatment approaches of skin pigmentation diseases and summarizes the research progress and mechanism of natural products with lightening or whitening effects that are clinically common or experimentally proven. Moreover, we outline the novel formulations of natural products in treating pigmentation disorders, including liposomes, nanoparticles, microemulsions, microneedles, and tocosomes. Finally, the pharmacodynamic evaluation methods in the study of pigmentation disorder were first systematically analyzed. In brief, this review aims to collect natural products for skin pigmentation treatment and investigate their formulation design and efficacy evaluation to provide insights for the development of new products for this complex skin disease.
皮肤色素沉着通常源于黑色素的过度分泌和积累，导致肤色比正常皮肤更深。目前，局部应用化学药物是色素沉着疾病的一线治疗策略，但药物的安全性和有效性仍无法满足临床治疗需求。为了实现长期安全用药，研究人员将目光投向了生物相容性更高的天然产物。本文首先探讨皮肤色素沉着疾病的发病机制和治疗方法，总结临床上常用或经实验证实具有美白或淡斑效果的天然产物的研究进展及作用机制。此外，我们概述了天然产物在治疗色素沉着疾病方面的新型制剂，包括脂质体、纳米颗粒、微乳、微针和生育酚体。最后系统性地分析了色素沉着疾病研究中的药效学评价方法。简而言之，本综述旨在收集用于治疗皮肤色素沉着的天然产物，并研究它们的制剂设计和疗效评价，为开发针对这种复杂皮肤疾病的新产品提供思路。
