硝酰基（HNO）的药理学及其治疗潜力：不只是一氧化氮（NO）的两面性。
The pharmacology of nitroxyl (HNO) and its therapeutic potential: not just the Janus face of NO.
作者信息
Paolocci Nazareno, Jackson Matthew I, Lopez Brenda E, Miranda Katrina, Tocchetti Carlo G, Wink David A, Hobbs Adrian J, Fukuto Jon M
机构信息
Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.
出版信息
Pharmacol Ther. 2007 Feb;113(2):442-58. doi: 10.1016/j.pharmthera.2006.11.002. Epub 2006 Nov 29.
Abstract
Nitroxyl (HNO), the 1-electron reduced and protonated congener of nitric oxide (NO), has received recent attention as a potential pharmacological agent for the treatment of heart failure and as a preconditioning agent for the mitigation of ischemia-reperfusion injury. Interest in the pharmacology and biology of HNO has prompted examination, or in some instances reexamination, of many of its chemical properties. Such studies have provided insight into the chemical basis for the biological effects of HNO, although the biochemical mechanisms for many of these effects remain to be established. In this review, a brief description of the biologically relevant chemistry of HNO is given, followed by a more detailed discussion of the pharmacology and potential toxicology of HNO.
摘要
硝酰（HNO）是一氧化氮（NO）单电子还原并质子化后的类似物，最近作为治疗心力衰竭的潜在药物以及减轻缺血再灌注损伤的预处理剂受到关注。对HNO药理学和生物学的兴趣促使人们对其许多化学性质进行研究，在某些情况下是重新研究。这些研究为HNO生物学效应的化学基础提供了见解，尽管其中许多效应的生化机制仍有待确定。在本综述中，首先简要描述了与HNO生物学相关的化学性质，随后更详细地讨论了HNO的药理学和潜在毒理学。
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本文引用的文献
1
Hydrolysis of acyloxy nitroso compounds yields nitroxyl (HNO).酰氧基亚硝基化合物的水解会产生硝酰（HNO）。
J Am Chem Soc. 2006 Aug 2;128(30):9687-92. doi: 10.1021/ja062365a.
2
Cathepsin B is a differentiation-resistant target for nitroxyl (HNO) in THP-1 monocyte/macrophages.组织蛋白酶B是THP-1单核细胞/巨噬细胞中硝酰基（HNO）的抗分化靶点。
Free Radic Biol Med. 2006 Jul 1;41(1):120-31. doi: 10.1016/j.freeradbiomed.2006.03.016. Epub 2006 May 4.
3
Role of nitric oxide in cardiovascular adaptation to intermittent hypoxia.一氧化氮在心血管系统对间歇性缺氧适应中的作用。
Exp Biol Med (Maywood). 2006 Apr;231(4):343-65. doi: 10.1177/153537020623100401.
4
Discriminating formation of HNO from other reactive nitrogen oxide species.区分由其他活性氮氧化物生成一氧化氮（HNO）的过程。
Free Radic Biol Med. 2006 Mar 15;40(6):1056-66. doi: 10.1016/j.freeradbiomed.2005.10.058. Epub 2005 Nov 21.
5
Mechanism of pH-dependent decomposition of monoalkylamine diazeniumdiolates to form HNO and NO, deduced from the model compound methylamine diazeniumdiolate, density functional theory, and CBS-QB3 calculations.从模型化合物甲胺重氮二醇盐、密度泛函理论和CBS-QB3计算推导单烷基胺重氮二醇盐pH依赖性分解形成HNO和NO的机制。
Inorg Chem. 2006 Mar 20;45(6):2448-56. doi: 10.1021/ic051505z.
6
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J Am Chem Soc. 2006 Feb 8;128(5):1422-3. doi: 10.1021/ja057097f.
7
N-Nitroso products from the reaction of indoles with Angeli's salt.吲哚与安吉利盐反应生成的N-亚硝基产物。
Chem Res Toxicol. 2006 Jan;19(1):58-67. doi: 10.1021/tx050253b.
8
The emerging biology of the nitrite anion.亚硝酸根阴离子的新兴生物学
Nat Chem Biol. 2005 Nov;1(6):308-14. doi: 10.1038/nchembio1105-308.
9
CO as a cellular signaling molecule.一氧化碳作为一种细胞信号分子。
Annu Rev Pharmacol Toxicol. 2006;46:411-49. doi: 10.1146/annurev.pharmtox.46.120604.141053.
10
Comparison of the NO and HNO donating properties of diazeniumdiolates: primary amine adducts release HNO in Vivo.二氮烯二醇盐的一氧化氮和一氧化氢供体性质比较：伯胺加合物在体内释放一氧化氢。
J Med Chem. 2005 Dec 29;48(26):8220-8. doi: 10.1021/jm050151i.
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