Suppr超能文献

评估周围神经损伤后新治疗方案的考量因素:一项关于用于研究感觉、运动和功能恢复方法的前瞻性临床研究。

Considerations in evaluating new treatment alternatives following peripheral nerve injuries: a prospective clinical study of methods used to investigate sensory, motor and functional recovery.

作者信息

Aberg M, Ljungberg C, Edin E, Jenmalm P, Millqvist H, Nordh E, Wiberg M

机构信息

Department of Hand & Plastic Surgery, Umeå University Hospital, Umeå, Sweden.

出版信息

J Plast Reconstr Aesthet Surg. 2007;60(2):103-13. doi: 10.1016/j.bjps.2006.04.019. Epub 2006 Jul 28.

Abstract

The current problem finding reliable and objective methods for evaluating results after peripheral nerve repair is a challenge when introducing new clinical techniques. The aim of this study was to obtain reference material and to evaluate the applicability of different tests used for clinical assessment after peripheral nerve injuries. Fifteen patients with a history of complete median nerve transsection and repair, and 15 healthy volunteers were included. Each subject was investigated using a battery of conventional and new tests for functional, sensory and motor recovery including questionnaires, clinical evaluations, neurophysiological and physiological findings. The results were statistically analysed and comparisons were made within the patient group and between patients and healthy volunteers using a 'per protocol' and an 'intention to treat' approach. Criteria for success were stipulated in order to be able to judge the usefulness of each method. The results showed that 19 of 34 variables, representing six of 16 methods, were not able to fulfil the criteria and were thus questionable for the evaluations of nerve repair in a clinical trial setting. However, 2pd, sensory recovery according to the non-modified British Medical Research Council, sensory neurography, manual muscle test, electromyography, questionnaires (i.e. DASH and the 4 question form) and performance tests (i.e. AMPS and Sollerman's subtests 4 and 8) did fulfil the criteria defined for being useful.

摘要

目前,在引入新的临床技术时,寻找可靠且客观的方法来评估周围神经修复后的结果是一项挑战。本研究的目的是获取参考材料,并评估用于周围神经损伤后临床评估的不同测试的适用性。纳入了15例有正中神经完全横断和修复病史的患者以及15名健康志愿者。使用一系列传统和新的测试对每个受试者进行功能、感觉和运动恢复情况的调查,包括问卷调查、临床评估、神经生理学和生理学检查结果。对结果进行统计分析,并采用“按方案”和“意向性分析”方法在患者组内以及患者与健康志愿者之间进行比较。规定了成功标准,以便能够判断每种方法的有用性。结果显示,代表16种方法中6种方法的34个变量中的19个未能满足标准,因此在临床试验环境中对神经修复评估而言存在疑问。然而,两点辨别觉、按照未修改的英国医学研究委员会标准的感觉恢复情况、感觉神经电图、徒手肌力测试、肌电图、问卷调查(即上肢功能障碍评定量表和4项问题表格)以及性能测试(即上肢运动功能测试和索勒曼测试的第4项和第8项子测试)确实满足了被定义为有用的标准。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验