Kim Albert H, Bonni Azad
Department of Pathology, Harvard Medical School, New Research Building, 77 Ave Louis Pasteur, Room 856, Boston, MA 02115, USA.
Mol Cell Neurosci. 2007 Mar;34(3):281-7. doi: 10.1016/j.mcn.2006.11.019. Epub 2007 Jan 12.
The anaphase-promoting complex (APC) has a well-established role in cell cycle control, but recent exciting evidence has uncovered unexpected neurobiological functions for this complex E3 ubiquitin ligase. With its co-activator Cdh1, APC's effects upon the nervous system range from regulation of axon growth and patterning to development of synapses to neuronal survival. The Cdh1-APC substrates that control these biological processes in neurons are just beginning to be identified. These findings may offer a glimpse of the wide spectrum of neural activities that are orchestrated by Cdh1-APC.
后期促进复合物（APC）在细胞周期调控中具有公认的作用，但最近令人兴奋的证据揭示了这种E3泛素连接酶复合物意想不到的神经生物学功能。与其共激活因子Cdh1一起，APC对神经系统的影响范围从轴突生长和模式的调节到突触发育再到神经元存活。控制神经元中这些生物学过程的Cdh1-APC底物才刚刚开始被确定。这些发现可能让我们初步了解由Cdh1-APC精心编排的广泛神经活动。
