动态泛素连接酶对：Cdh1-APC 和 Cdc20-APC 调节神经元形态发生和连接。
The dynamic ubiquitin ligase duo: Cdh1-APC and Cdc20-APC regulate neuronal morphogenesis and connectivity.
机构信息
Department of Pathology, Harvard Medical School, Boston, MA 02115, USA; Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Curr Opin Neurobiol. 2010 Feb;20(1):92-9. doi: 10.1016/j.conb.2009.12.004. Epub 2010 Jan 7.
Abstract
The proper development and patterning of axons, dendrites, and synapses is essential for the establishment of accurate neuronal circuits in the brain. A major goal in neurobiology is to identify the mechanisms and principles that govern these fundamental developmental events of neuronal circuit formation. In recent years, exciting new studies have suggested that ubiquitin signaling pathways may play crucial roles in the control of neuronal connectivity. Among E3 ubiquitin ligases, Cdh1-anaphase promoting complex (Cdh1-APC) and Cdc20-APC have emerged as key regulators of diverse aspects of neuronal connectivity, from axon and dendrite morphogenesis to synapse differentiation and remodeling.
摘要
轴突、树突和突触的正常发育和模式形成对于大脑中准确的神经元回路的建立至关重要。神经生物学的主要目标是确定控制神经元回路形成的这些基本发育事件的机制和原则。近年来，令人兴奋的新研究表明，泛素信号通路可能在控制神经元连接中发挥关键作用。在 E3 泛素连接酶中，Cdh1-有丝分裂促进复合物（Cdh1-APC）和 Cdc20-APC 已成为神经元连接的多个方面的关键调节剂，包括轴突和树突形态发生、突触分化和重塑。
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