与用于类风湿关节炎的肿瘤坏死因子-α抑制剂相关的穿凿性毛囊炎。

Perforating folliculitis associated with tumour necrosis factor-alpha inhibitors administered for rheumatoid arthritis.

作者信息

Gilaberte Y, Coscojuela C, Vázquez C, Roselló R, Vera J

机构信息

Deapartment of Dermatology, San Jorge General Hospital, Huesca, Spain.

出版信息

Br J Dermatol. 2007 Feb;156(2):368-71. doi: 10.1111/j.1365-2133.2006.07598.x.

DOI:10.1111/j.1365-2133.2006.07598.x

PMID:17223880

Abstract

Perforating dermatoses are characterized by transepithelial elimination of dermal structures. We report a 61-year-old man with rheumatoid arthritis who developed a perforating folliculitis following the administration of two tumour necrosis factor (TNF)-alpha inhibitors, infliximab and etanercept. To our knowledge, no perforating disorders have been reported associated with these drugs. This report suggests, for the first time, a role for TNF-alpha in the pathogenesis of perforating folliculitis.

摘要

穿通性皮肤病的特征是真皮结构经上皮排出。我们报告一名61岁的类风湿性关节炎男性患者，在使用两种肿瘤坏死因子（TNF）-α抑制剂英夫利昔单抗和依那西普后发生了穿通性毛囊炎。据我们所知，尚无与这些药物相关的穿通性疾病的报道。本报告首次提示TNF-α在穿通性毛囊炎发病机制中的作用。