Edek Yusuf Can, Aypek Yağmur, Öğüt Betül, Erdem Özlem, Adışen Esra
Department of Dermatology, Gazi University Faculty of Medicine, Ankara, Turkey.
Department of Pathology, Gazi University Faculty of Medicine, Ankara, Turkey.
Dermatol Pract Concept. 2024 Apr 1;14(2):e2024100. doi: 10.5826/dpc.1402a100.
Acquired perforating dermatosis (APD) is a disease group characterized by transepidermal elimination of dermal connective tissue materials such as collagen, elastic fibers, and keratin through the epidermis and observed with pruritic skin lesions.
In this study, we aim to clarify the clinical, histopathological, and dermoscopic characteristics of APD, identify the associated systemic disease, and figure out treatment options.
This study was designed as a single-center retrospective, observational, cross-sectional study. We evaluated all accessible APD cases between January 2004 and June 2022 in a tertiary care hospital.
A total of 95 patients with confirmed APD were included in the study. Sixty percent of the patients were women and 40% were men. The median age at diagnosis was 63.1 years (35-85 years). The most common site of lesions was the lower extremities which were detected in 86.31% of the patients. The concomitant systemic disease was identified in 84.21% of the patients. The most common systemic disease was type 2 diabetes mellitus (65.26%). Antihistamines and topical corticosteroids were the most commonly prescribed treatment agents.
Transepidermal elimination of dermal connective tissue components is a feature of APD and the disease usually presents with pruritic papules and nodules with central keratotic crust or plug. The diagnosis of APD requires a clinical examination and histological investigation. APD is usually accompanied by systemic comorbidities. There are several topical and systemic medications available for APD, however, sometimes the therapy might be challenging.
获得性穿通性皮肤病（APD）是一组以真皮结缔组织物质（如胶原蛋白、弹性纤维和角蛋白）经表皮排出为特征，并伴有瘙痒性皮肤损害的疾病。
在本研究中，我们旨在阐明APD的临床、组织病理学和皮肤镜特征，确定相关的全身性疾病，并找出治疗方案。
本研究设计为一项单中心回顾性观察性横断面研究。我们评估了2004年1月至2022年6月期间在一家三级护理医院就诊的所有可获取的APD病例。
本研究共纳入95例确诊为APD的患者。其中60%为女性，40%为男性。诊断时的中位年龄为63.1岁（35 - 85岁）。最常见的皮损部位是下肢，86.31%的患者在此部位出现病变。84.21%的患者伴有全身性疾病。最常见的全身性疾病是2型糖尿病（65.26%）。抗组胺药和外用糖皮质激素是最常用的治疗药物。
真皮结缔组织成分经表皮排出是APD的一个特征，该疾病通常表现为伴有中央角化性痂皮或栓子的瘙痒性丘疹和结节。APD的诊断需要临床检查和组织学检查。APD通常伴有全身性合并症。有几种外用和全身性药物可用于治疗APD，然而，有时治疗可能具有挑战性。
