Kapur Payal, Erickson Christof, Rakheja Dinesh, Carder K Robin, Hoang Mai P
Department of Pathology, Children's Medical Center Dallas, Texas, USA.
J Am Acad Dermatol. 2007 Feb;56(2):290-4. doi: 10.1016/j.jaad.2006.09.001.
The real incidence of congenital self-healing reticulohistiocytosis (CSHR) may be underreported because of its high rate of spontaneous resolution and lack of clinical recognition. Currently, there are no criteria other than clinical that can reliably distinguish CSHR from cutaneous involvement by disseminated Langerhans cell histiocytosis (LCH). In this study we investigate the role of E-cadherin, Ki-67, and phosphorylated histone H3 (PHH3) immunohistochemical stains in distinguishing CSHR from disseminated LCH. We found that no significant difference was seen in the histologic features and the expression of E-cadherin, Ki-67, and PHH3 between the two groups; thus supporting the theory that CSHR and LCH represent different ends of a spectrum of the same condition.
先天性自愈性网状组织细胞增多症（CSHR）的实际发病率可能被低估，因为其自发缓解率高且缺乏临床认识。目前，除了临床症状外，没有其他标准能够可靠地将CSHR与播散性朗格汉斯细胞组织细胞增多症（LCH）的皮肤受累区分开来。在本研究中，我们调查了E-钙黏蛋白、Ki-67和磷酸化组蛋白H3（PHH3）免疫组化染色在区分CSHR与播散性LCH中的作用。我们发现两组之间在组织学特征以及E-钙黏蛋白、Ki-67和PHH3的表达方面均未观察到显著差异；因此支持了CSHR和LCH代表同一疾病谱不同端点的理论。
