Rogo K O, Onyango G K, Ojwang P J, Sekkade-Kigondu C
Department of Obstetrics and Gynaecology, College of Health Sciences, University of Nairobi.
East Afr Med J. 1991 Aug;68(8):601-5.
In a prospective and cross-sectional study, 147 serum samples from normal antenatal indigenous Kenyan women were analysed for alpha-fetoprotein (AFP) concentrations between 8 and 28 weeks gestation. There was progressive rise in AFP levels with gestation, most rapid between 12 and 24 weeks. There were wide variations in AFP concentrations at every gestation but no correlation was established with maternal age or parity. All the eleven women with very high AFP values had subsequent complications, including 2 abortions, 1 APH, 7 PET and one pair of twins. The need for more studies on the value of AFP in monitoring of pregnancy in the African set up is emphasised.
在一项前瞻性横断面研究中，对147份来自肯尼亚本土正常产前妇女的血清样本进行了分析，以测定妊娠8至28周期间的甲胎蛋白（AFP）浓度。AFP水平随孕周逐渐升高，在12至24周之间升高最快。每个孕周的AFP浓度存在很大差异，但与母亲年龄或产次未建立相关性。所有11名AFP值非常高的妇女随后都出现了并发症，包括2例流产、1例产前出血、7例子痫前期和1例双胞胎。强调了有必要在非洲背景下就AFP在监测妊娠中的价值开展更多研究。
