Furukawa H, Hara T, Hoshino K, Taniguchi T
Department of Surgery, Shimizu Kosei Hospital, Japan.
Gastroenterol Jpn. 1991 Dec;26(6):779-82. doi: 10.1007/BF02782868.
A 63-year-old Japanese woman who was being treated for liver cirrhosis was diagnosed as having hepatocellular carcinoma in the caudate lobe of the liver. Transcatheter hepatic arterial chemoembolization was performed for this lesion, but severe neutropenia occurred. To restore white blood cell (WBC) counts, recombinant human granulocyte colony-stimulating factor (rhG-CSF) was administered (250 micrograms per day during 10 days, intravenously). Subsequently, WBC counts recovered immediately without side effects. This suggests that rhG-CSF could be useful for the treatment of neutropenia after chemoembolization, even in cirrhotic patients.
一名正在接受肝硬化治疗的63岁日本女性被诊断出肝尾状叶患有肝细胞癌。对该病灶进行了经导管肝动脉化疗栓塞术，但出现了严重的中性粒细胞减少症。为了恢复白细胞（WBC）计数，给予了重组人粒细胞集落刺激因子（rhG-CSF）（每天250微克，持续10天，静脉注射）。随后，白细胞计数立即恢复，且无副作用。这表明rhG-CSF即使对肝硬化患者，也可能对化疗栓塞术后的中性粒细胞减少症治疗有用。
