Pan W, Kastin A J
Blood-Brain Barrier Lab, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
Int J Obes (Lond). 2007 Jun;31(6):1030-2. doi: 10.1038/sj.ijo.0803536. Epub 2007 Jan 16.
Avy/agouti (Avy) mice have late onset obesity related to overexpression of agouti signaling protein (ASP) in the hypothalamus. As mahogany modulates the actions of ASP, we tested the transport of mahogany peptide across the blood-brain barrier (BBB). The brain uptake of mahogany peptide was significantly higher in young Avy mice, and it preceded the surge of fat mass quantified by nuclear magnetic resonance. The results suggest a role of accelerated BBB transport in the epigenetics of Avy mice.
Avy/刺鼠（Avy）小鼠存在与下丘脑刺鼠信号蛋白（ASP）过度表达相关的迟发性肥胖。由于桃花心木基因调节ASP的作用，我们测试了桃花心木肽穿过血脑屏障（BBB）的转运情况。在年轻的Avy小鼠中，桃花心木肽的脑摄取量显著更高，且早于通过核磁共振定量的脂肪量激增。结果表明血脑屏障转运加速在Avy小鼠表观遗传学中发挥作用。
