Goñi F, Oleaga A, Goñi M J, Monreal M, Yoldi A, González A, Llorente I, Moncada E
Departamento de Endocrinología, Clínica Universitaria de Navarra, Pamplona.
Rev Clin Esp. 1991 Nov;189(7):331-4.
Over the past few years the usefulness of some somatostatin's analogues in the treatment of intestinal tract endocrine tumors has been demonstrated. Notwithstanding, the results obtained are variable. The case of a carcinoid tumor with a hepatic metastasis is presented and its clinical as well as its biochemical and its morphological results are evaluated after treatment with octreotide over a seven months period. It is important to highlight the great clinical improvement obtained at the beginning of treatment. Treatment was not effective in the control of tumor progression. After the injection of such a drug, a decrease in serotonin and 5-hydroxy-indoleacetic acid serum levels was observed as well as a reduction in the urinary metabolite. It is concluded that octreotide is very useful for the symptomatic treatment of carcinoid syndrome.
在过去几年中，已证明某些生长抑素类似物在治疗肠道内分泌肿瘤方面的有效性。尽管如此，所获得的结果却不尽相同。本文介绍了一例伴有肝转移的类癌肿瘤病例，并在使用奥曲肽治疗七个月后评估了其临床、生化和形态学结果。重要的是要强调在治疗开始时取得的巨大临床改善。治疗对控制肿瘤进展无效。注射这种药物后，观察到血清中血清素和5-羟吲哚乙酸水平降低，尿代谢产物也减少。得出的结论是，奥曲肽对类癌综合征的对症治疗非常有用。
