经鼻暴露后环境假单胞菌在小鼠体内的分布、清除及死亡率
Distribution, clearance, and mortality of environmental pseudomonads in mice upon intranasal exposure.
作者信息
George S E, Kohan M J, Whitehouse D A, Creason J P, Kawanishi C Y, Sherwood R L, Claxton L D
机构信息
Health Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711.
出版信息
Appl Environ Microbiol. 1991 Aug;57(8):2420-5. doi: 10.1128/aem.57.8.2420-2425.1991.
Abstract
When introduced intranasally, P. cepacia AC1100 (approximately 10(8) CFU/animal) and P. aeruginosa AC869 (approximately 10(3) CFU/animal) were readily cleared from the mouse. However, a approximately 10(7)-CFU dose of AC869 persisted for 14 days. Strain AC869 had a 50% lethal dose of 2.7 x 10(7) CFU. Slight morbidity occurred in animals treated with approximately 10(7) CFU of AC869 or approximately 10(8) CFU of AC1100.
摘要
经鼻内接种时，洋葱伯克霍尔德菌AC1100（约10⁸CFU/动物）和铜绿假单胞菌AC869（约10³CFU/动物）很容易从小鼠体内清除。然而，约10⁷CFU剂量的AC869在小鼠体内持续存在了14天。菌株AC869的半数致死剂量为2.7×10⁷CFU。用约10⁷CFU的AC869或约10⁸CFU的AC1100处理的动物出现了轻微发病症状。
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