丙戊酸对体内海马透析液中5-羟色胺和5-羟吲哚乙酸浓度的影响。
The effect of valproic acid on 5-hydroxytryptamine and 5-hydroxyindoleacetic acid concentration in hippocampal dialysates in vivo.
作者信息
Whitton P S, Fowler L J
机构信息
Department of Pharmacology, School of Pharmacy, Brunswick Square, London, U.K.
出版信息
Eur J Pharmacol. 1991 Jul 23;200(1):167-9. doi: 10.1016/0014-2999(91)90681-f.
The effect of valproic acid (100, 200 and 400 mg/kg i.p.) on extracellular 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) has been studied using intracerebral microdialysis of the ventral hippocampus. Valproate caused a dose-dependent increase in dialysate 5-HT, but in contrast no effect on 5-HIAA level was observed. These findings are considered with regard to a possible role of 5-HT in mediating the anticonvulsant action of valproate.
使用腹侧海马脑内微透析技术，研究了丙戊酸（腹腔注射，剂量分别为100、200和400mg/kg）对细胞外5-羟色胺（5-HT）和5-羟吲哚乙酸（5-HIAA）的影响。丙戊酸盐使透析液中5-HT呈剂量依赖性增加，但与之相反，未观察到对5-HIAA水平有影响。结合5-HT在介导丙戊酸盐抗惊厥作用中可能发挥的作用，对这些发现进行了探讨。
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