Sonpavde Guru, Hutson Thomas E, Roth Bruce J
US Oncology Research, Houston, Texas, USA.
Oncologist. 2007 Jan;12(1):51-61. doi: 10.1634/theoncologist.12-1-51.
Although front-line chemotherapy cures most men with testicular germ cell tumors, salvage therapy is still important in a small but significant minority. Second-line conventional-dose or high-dose chemotherapy with stem cell rescue may cure 25%-50% of patients. New chemotherapeutic agents, including the taxanes gemcitabine and oxaliplatin, have added to the therapeutic armamentarium. Salvage surgical resection has an important role in selected patients. Cisplatin-refractory patients have a poor prognosis with current therapy, and novel chemotherapeutic and biologic agents need to be discovered for such patients.
虽然一线化疗可治愈大多数睾丸生殖细胞肿瘤患者，但挽救性治疗对一小部分但数量可观的患者仍很重要。二线常规剂量或大剂量化疗联合干细胞救援可治愈25%-50%的患者。新的化疗药物，包括紫杉烷类、吉西他滨和奥沙利铂，已被纳入治疗手段。挽救性手术切除在部分患者中具有重要作用。顺铂难治性患者目前的治疗预后较差，需要为这类患者研发新的化疗和生物制剂。
