Kucia M, Ratajczak M Z
Stem Cell Biology Program at James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
J Physiol Pharmacol. 2006 Nov;57 Suppl 7:5-16.
Evidence has accumulated that quiescent stem cells or cells developmentally closely related to them distributed in various organs may be a cellular origin of cancer development. In support of this notion, stem cells (SC) are long-lived cells with distinctive properties of self-renewal and has the potential to proliferate extensively. Given these features, it's possible that they may become the subject of consecutive accumulated mutations that are crucial for initiation of cancer. Therefore, mutations that occur in normal stem cells might lead to their malignant transformation and tumor initiation. Furthermore, many biological features of normal and cancer SC such as the physiological trafficking of normal and metastasis of cancer stem cells involve similar molecular mechanisms, and we discuss these similarities here.
越来越多的证据表明，分布于各个器官中的静止干细胞或与其发育密切相关的细胞可能是癌症发生的细胞起源。支持这一观点的是，干细胞（SC）是具有自我更新独特特性的长寿细胞，并且具有广泛增殖的潜力。鉴于这些特征，它们有可能成为连续累积突变的对象，而这些突变对于癌症的起始至关重要。因此，正常干细胞中发生的突变可能导致其恶性转化和肿瘤起始。此外，正常干细胞和癌症干细胞的许多生物学特征，如正常干细胞的生理运输和癌症干细胞的转移，都涉及相似的分子机制，我们在此讨论这些相似之处。
