Snow Andrew L, Martinez Olivia M
Program in Immunology, Stanford University School of Medicine, Stanford, California, USA.
Am J Transplant. 2007 Feb;7(2):271-7. doi: 10.1111/j.1600-6143.2006.01650.x. Epub 2007 Jan 4.
Epstein-Barr virus (EBV) infection is linked to approximately 90% of B-cell lymphomas associated with posttransplant lymphoproliferative disease (PTLD), a serious complication for immunosuppressed transplant recipients. In this paper, we review the myriad ways by which EBV can inadvertently drive the genesis and persistence of B-cell lymphomas, particularly when the antiviral immune response is compromised. Probing the basic mechanisms by which EBV infection proceeds and contributes to malignancy in such cases will hopefully improve our understanding and treatment of PTLD and other EBV-associated malignancies.
爱泼斯坦-巴尔病毒（EBV）感染与大约90%的与移植后淋巴细胞增生性疾病（PTLD）相关的B细胞淋巴瘤有关，PTLD是免疫抑制移植受者的一种严重并发症。在本文中，我们综述了EBV可能无意中驱动B细胞淋巴瘤发生和持续存在的多种方式，尤其是在抗病毒免疫反应受损时。探究EBV感染在这些情况下发生并导致恶性肿瘤的基本机制，有望增进我们对PTLD和其他EBV相关恶性肿瘤的理解与治疗。
