Seifert Jessica R K, Mlodzik Marek
Brookdale Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.
Nat Rev Genet. 2007 Feb;8(2):126-38. doi: 10.1038/nrg2042.
Signalling through Frizzled (Fz)/planar cell polarity (PCP) is a conserved mechanism that polarizes cells along specific axes in a tissue. Genetic screens in Drosophila melanogaster pioneered the discovery of core PCP factors, which regulate the orientation of hairs on wings and facets in eyes. Recent genetic evidence shows that the Fz/PCP pathway is conserved in vertebrates and is crucial for disparate processes as gastrulation and sensory cell orientation. Fz/PCP signalling depends on complex interactions between core components, leading to their asymmetric distribution and ultimately polarized activity in a cell. Whereas several mechanistic aspects of PCP have been uncovered, the global coordination of this polarization remains debated.
通过卷曲蛋白（Fz）/平面细胞极性（PCP）进行的信号传导是一种保守机制，可使组织中的细胞沿特定轴极化。黑腹果蝇中的遗传筛选率先发现了核心PCP因子，这些因子调节翅膀上的毛和眼睛中小平面的方向。最近的遗传证据表明，Fz/PCP途径在脊椎动物中是保守的，并且对于诸如原肠胚形成和感觉细胞定向等不同过程至关重要。Fz/PCP信号传导取决于核心成分之间的复杂相互作用，导致它们在细胞中不对称分布并最终产生极化活性。尽管已经揭示了PCP的几个机制方面，但这种极化的全局协调仍存在争议。
