培哚普利对豚鼠发情周期及避孕治疗期间血浆和肾上腺皮质类固醇无影响。
Lack of effect of perindopril on plasma and adrenal corticosteroids in the guinea pig during the estrous cycle and under contraceptive treatment.
作者信息
Buisson S, Laurant P, Dalle M, Devissaguet M, Scalbert E
机构信息
Laboratoire de Physiologie Animale, Université Blaise Pascal-Clermont-Ferrand II, Ensemble Scientifique des Cézaux, France.
出版信息
Arch Int Physiol Biochim Biophys. 1991 Aug;99(4):287-90. doi: 10.3109/13813459109146938.
We studied changes in cortisol, aldosterone, progesterone, estrogens and cholesterol in cyclic female guinea-pigs and in animals under contraceptive, treated or not with an inhibitor of angiotensin converting enzyme (ACE): perindopril. Perindopril decreased ACE by 80% without affecting steroid profiles. Peak value for plasma progesterone occurred at meta-estrus and diestrus. It disappeared under contraceptive treatment. The very low levels of estrogens in the female guinea pig remained unchanged in all cases. Plasma cortisol concentrations were higher at pro-estrus and estrus whereas plasma aldosterone concentrations remained constant during the estrous cycle and under contraceptive treatment. Furthermore, aldosterone did not change under perindopril treatment despite the decrease of the activity of ACE. The contraceptive treatment decreased plasma cholesterol levels. Under perindopril treatment, this drop was amplified. No change was detected in adrenal steroid concentrations, except for progesterone which decreased under contraceptive treatment.
我们研究了周期性发情的雌性豚鼠以及接受避孕处理、用血管紧张素转换酶（ACE）抑制剂培哚普利治疗或未治疗的动物体内皮质醇、醛固酮、孕酮、雌激素和胆固醇的变化。培哚普利使ACE降低了80%，但不影响类固醇水平。血浆孕酮的峰值出现在发情后期和间情期。在避孕处理下，该峰值消失。雌性豚鼠体内极低水平的雌激素在所有情况下均保持不变。发情前期和发情期的血浆皮质醇浓度较高，而血浆醛固酮浓度在发情周期和避孕处理期间保持恒定。此外，尽管ACE活性降低，但培哚普利治疗并未使醛固酮发生变化。避孕处理降低了血浆胆固醇水平。在培哚普利治疗下，这种下降幅度增大。除了在避孕处理下孕酮降低外，肾上腺类固醇浓度未检测到变化。
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