瞬时受体电位通道在前列腺癌中的差异作用。
Differential role of TRP channels in prostate cancer.
作者信息
Prevarskaya N, Flourakis M, Bidaux G, Thebault S, Skryma R
机构信息
Inserm, U-800, Equipe labellisée par la Ligue Nationale contre le cancer, Villeneuve d'Ascq F-59655, France.
出版信息
Biochem Soc Trans. 2007 Feb;35(Pt 1):133-5. doi: 10.1042/BST0350133.
A major clinical problem with PC (prostate cancer) is the cell's ability to survive and proliferate upon androgen withdrawal. Indeed, deregulated cell differentiation and proliferation, together with the suppression of apoptosis, provides the condition for abnormal tissue growth. Here, we examine the differential role of TRP (transient receptor potential) channels in the control of Ca(2+) homoeostasis and growth of PC cells.
前列腺癌（PC）的一个主要临床问题是细胞在雄激素撤除后仍具有存活和增殖的能力。事实上，细胞分化和增殖失调，以及细胞凋亡受抑制，为异常组织生长创造了条件。在此，我们研究瞬时受体电位（TRP）通道在调控前列腺癌细胞钙（Ca2+）稳态及生长中的不同作用。
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