Chudakov Bella, Ben Zion Itzhak Z, Belmaker R H
Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheba, Israel.
Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheba, Israel.
J Sex Med. 2007 Jan;4(1):204-208. doi: 10.1111/j.1743-6109.2006.00405.x.
Several studies suggest that increased plasma testosterone can improve sexual function and desire in post-oophorectomy or postmenopausal women. However, side effects of chronic daily testosterone raise questions about the generalizability of this treatment approach. Sublingual testosterone was reported to cause testosterone levels to peak after 15 minutes and then decline to baseline levels within 90 minutes. Three to 4 hours after reaching testosterone peak, increased genital sensations and sexual lust were reported.
We hypothesized that a single dose of testosterone given 4-8 hours prior to planned intercourse in women with hypoactive sexual desire disorder (HSDD) might increase desire without side effects associated with chronic use.
The design was randomized double-blind crossover. Premenstrual women with HSDD received eight packets of gel or identical placebo for use before intercourse twice weekly for 1 month. For a second month, the alternate treatment was given.
Ratings were performed using the patient-rated Arizona Sexual Experiences Scale for females and the clinician-rated Sexual Function Questionnaire (SFQ-V1).
Ten patients completed the study. On the five-item self-report Arizona, the item "How easily are you aroused?" was significantly improved on testosterone gel vs. placebo, P = 0.03. There were similar trends on the physician-rated SFQ-V1 "arousal-sensation" cluster.
These preliminary results suggest that testosterone gel given prn before intercourse has effects on sexual arousal, and further research is needed to define dosage and time schedule to optimize this effect and determine its clinical relevance.
多项研究表明，血浆睾酮水平升高可改善卵巢切除术后或绝经后女性的性功能和性欲。然而，长期每日使用睾酮的副作用引发了对这种治疗方法普遍适用性的质疑。据报道，舌下含服睾酮会使睾酮水平在15分钟后达到峰值，然后在90分钟内降至基线水平。在达到睾酮峰值3至4小时后，有报道称生殖器感觉增强和性欲增加。
我们假设，对于性欲减退障碍（HSDD）女性，在计划性交前4至8小时给予单剂量睾酮可能会增加性欲，且无长期使用相关的副作用。
设计为随机双盲交叉试验。患有HSDD的经前期女性接受八包凝胶或相同的安慰剂，每周两次在性交前使用，持续1个月。第二个月给予交替治疗。
使用患者自评的女性亚利桑那性体验量表和临床医生评定的性功能问卷（SFQ-V1）进行评分。
10名患者完成了研究。在五项自评的亚利桑那量表中，“你有多容易被唤起性欲？”这一项在睾酮凝胶组与安慰剂组相比有显著改善（P = 0.03）。在医生评定的SFQ-V1“唤起感觉”类别中也有类似趋势。
这些初步结果表明，性交前按需给予睾酮凝胶对性唤起有影响，需要进一步研究来确定优化这种效果的剂量和时间表，并确定其临床相关性。
