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Synthesis and QSAR studies on hypotensive 1-[3-(4-substituted phenylthio) propyl]-4-(substituted phenyl) piperazines.

作者信息

Saxena Anil K, Rao Jyoti, Chakrabarty Ruchika, Saxena Mridula, Srimal R C

机构信息

Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, India.

出版信息

Bioorg Med Chem Lett. 2007 Mar 15;17(6):1708-12. doi: 10.1016/j.bmcl.2006.12.072. Epub 2006 Dec 23.

Abstract

A series of 1-[3-(4-substituted phenylthio) propyl]-4-(substituted phenyl) piperazines has been synthesized and evaluated for hypotensive activity. The QSAR studies indicate that resonance and hydrophobic parameters of the aryl substituents are important for hypotensive activity. The similar role of resonance parameter in describing the variance of 5-HT(2A) receptor binding affinities of these compounds suggests a possible role of 5-HT(2A) receptors in mediating the hypotensive action of title compounds.

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