Gorczyca M, Pawłowski M, Mrozikiewicz A, Kozłowska T, Wasik A
Pol J Pharmacol Pharm. 1986 Jan-Feb;38(1):85-90.
In order to examine the circulatory and bronchospasmolytic activity, new 7-beta-hydroxy-gamma-N4-alkylpiperazinopropyl-8- benzylaminotheophyllines (1, 2, 3) were synthesized and converted to the water soluble dihydrochlorides (1a, 2a, 3a). They showed hypotensive and bronchodilatory effect.