胃腺癌胃切除患者中三联疗法根除幽门螺杆菌疗效的评估
Evaluation of the efficacy of triple therapy regimen for Helicobacter pylori eradication in gastrectomized patients with gastric adenocarcinoma.
作者信息
Bertoli Neto Jose Luiz, Lourenço Laercio Gomes, Bertoli Cícero Fernando, Ulbrich Fábio Samsonowski, Sabbi Antoninho Ricardo, Bueno Alexandre Galvão
机构信息
Department of Surgery, Fellow of Universidade Federal de São Paulo -- Escola-Paulista de Medicina, São Paulo, Brazil.
出版信息
Gastric Cancer. 2006;9(4):291-4. doi: 10.1007/s10120-006-0393-4. Epub 2006 Nov 24.
BACKGROUND
The cause of cancer in the gastric stump is multifactorial, and Helicobacter pylori is one of these factors. Its eradication has been recommended; however, there are few studies about of H. pylori eradication in gastrectomized patients.
METHODS
Twenty gastrectomized patients with gastric adenocarcinoma and Roux-en-Y reconstruction (study group) infected by H. pylori were compared with nongastrectomized patients (control group) also infected by H. pylori. The presence of H. pylori was determined by the ultra-quick urease test and from a histological sample obtained by endoscopy. Both groups received the same triple therapy regimen.
RESULTS
The rate of eradication of H. pylori in the study group was 90% and in the control group, it was 85%. Sex, age, and postoperative time did not influence the rate of eradication.
CONCLUSION
There were no differences in the efficacy of H. pylori eradication between the two groups; therefore, the triple therapy regimen is effective for the eradication of H. pylori in gastrectomized patients with a Roux-en-Y reconstruction.
背景
残胃癌的病因是多因素的，幽门螺杆菌是其中一个因素。已建议根除幽门螺杆菌；然而，关于胃切除患者幽门螺杆菌根除的研究很少。
方法
将20例接受胃腺癌手术并采用Roux-en-Y重建术的幽门螺杆菌感染胃切除患者（研究组）与同样感染幽门螺杆菌的非胃切除患者（对照组）进行比较。通过超快速尿素酶试验和内镜获取的组织学样本确定幽门螺杆菌的存在。两组均接受相同的三联疗法方案。
结果
研究组幽门螺杆菌根除率为90%，对照组为85%。性别、年龄和术后时间不影响根除率。
结论
两组间幽门螺杆菌根除疗效无差异；因此，三联疗法方案对采用Roux-en-Y重建术的胃切除患者根除幽门螺杆菌有效。
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