Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: differences of bioactivity in the enantiomeric series.
作者信息
Mente Nolan R, Wiemer Andrew J, Neighbors Jeffrey D, Beutler John A, Hohl Raymond J, Wiemer David F
机构信息
Department of Chemistry, University of Iowa, Iowa City, IA 52242-1294, USA.
出版信息
Bioorg Med Chem Lett. 2007 Feb 15;17(4):911-5. doi: 10.1016/j.bmcl.2006.11.096. Epub 2006 Dec 12.
PMID:17236766
Abstract
Total synthesis of the (R,R,R)- and (S,S,S)-enantiomers of the natural product schweinfurthin F has been completed. Comparisons of spectral data and optical rotations with those reported for the natural product, as well as a variety of bioassay data, allow assignment of the natural material as the (R,R,R)-isomer.
摘要
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