• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

施温富菌素A - Q：分离、合成及生化特性

Schweinfurthins A-Q: isolation, synthesis, and biochemical properties.

作者信息

Harmalkar Dipesh S, Mali Jyotirling R, Sivaraman Aneesh, Choi Yongseok, Lee Kyeong

机构信息

College of Pharmacy, Dongguk University-Seoul Goyang 10326 Republic of Korea

Department of Biotechnology, Korea University Seoul 02841 Republic of Korea.

出版信息

RSC Adv. 2018 Jun 8;8(38):21191-21209. doi: 10.1039/c8ra02872a.

DOI:10.1039/c8ra02872a
PMID:35539907
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9080957/
Abstract

Stilbene analogues have shown remarkable structural diversity constituting simple or tangled structures, which have attracted the synthetic as well as the medicinal chemistry communities. Schweinfurthins are a family of prenylated/geranylated/farnesylated stilbenes that are isolated from an African plant belonging to the species. These compounds have displayed potency towards central nervous system, renal and breast cancer cell lines. Specifically, these compounds have been found to be potent and selective inhibitors of cell growth in the National Cancer Institute's 60 cell-line screen. In this review article, we described the isolation, synthesis, and biochemical properties of schweinfurthins.

摘要

芪类似物展现出显著的结构多样性，构成简单或复杂的结构，这吸引了合成化学和药物化学领域的关注。施温富菌素是一类异戊烯基化/香叶基化/法尼基化的芪类化合物，从属于该物种的一种非洲植物中分离得到。这些化合物对中枢神经系统、肾和乳腺癌细胞系显示出活性。具体而言，在国立癌症研究所的60种细胞系筛选中，发现这些化合物是细胞生长的强效和选择性抑制剂。在这篇综述文章中，我们描述了施温富菌素的分离、合成及生化特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/9e4494b04133/c8ra02872a-s20.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/d320c126cf2b/c8ra02872a-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/86ef9452f051/c8ra02872a-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/210b72acbcba/c8ra02872a-s5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/1dd94f386e90/c8ra02872a-s6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/5271032afc25/c8ra02872a-s7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/b01b91b18abf/c8ra02872a-s8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/6b3537d5287d/c8ra02872a-s9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/06de664412f2/c8ra02872a-s10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/0c3505040450/c8ra02872a-s11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/c8756e2c83d6/c8ra02872a-s12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/7547b5006482/c8ra02872a-s13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/d607aba604ab/c8ra02872a-s14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/6469e05b54da/c8ra02872a-s15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/00e1d0e4ded9/c8ra02872a-s16.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/f65b45b8055d/c8ra02872a-s17.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/0862e268009a/c8ra02872a-s18.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/4d4fbca28154/c8ra02872a-s19.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/9e4494b04133/c8ra02872a-s20.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/d320c126cf2b/c8ra02872a-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/86ef9452f051/c8ra02872a-s4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/210b72acbcba/c8ra02872a-s5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/1dd94f386e90/c8ra02872a-s6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/5271032afc25/c8ra02872a-s7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/b01b91b18abf/c8ra02872a-s8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/6b3537d5287d/c8ra02872a-s9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/06de664412f2/c8ra02872a-s10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/0c3505040450/c8ra02872a-s11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/c8756e2c83d6/c8ra02872a-s12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/7547b5006482/c8ra02872a-s13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/d607aba604ab/c8ra02872a-s14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/6469e05b54da/c8ra02872a-s15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/00e1d0e4ded9/c8ra02872a-s16.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/f65b45b8055d/c8ra02872a-s17.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/0862e268009a/c8ra02872a-s18.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/4d4fbca28154/c8ra02872a-s19.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08d6/9080957/9e4494b04133/c8ra02872a-s20.jpg

相似文献

1
Schweinfurthins A-Q: isolation, synthesis, and biochemical properties.施温富菌素A - Q：分离、合成及生化特性
RSC Adv. 2018 Jun 8;8(38):21191-21209. doi: 10.1039/c8ra02872a.
2
Cytotoxic Prenylated Stilbenes Isolated from Macaranga tanarius.从 Macaranga tanarius 中分离得到的细胞毒性芪类化合物。
J Nat Prod. 2017 Oct 27;80(10):2684-2691. doi: 10.1021/acs.jnatprod.7b00409. Epub 2017 Oct 3.
3
Fluorescent schweinfurthin B and F analogs with anti-proliferative activity.具有抗增殖活性的荧光 Schweinfurthin B 和 F 类似物。
Bioorg Med Chem. 2010 Sep 15;18(18):6734-41. doi: 10.1016/j.bmc.2010.07.056. Epub 2010 Jul 29.
4
Structural analogues of schweinfurthin F: probing the steric, electronic, and hydrophobic properties of the D-ring substructure.结构类似物的 Schweinfurthin F：探测 D-环亚结构的空间位阻、电子和疏水性。
Bioorg Med Chem. 2010 Feb 15;18(4):1676-83. doi: 10.1016/j.bmc.2009.12.063. Epub 2010 Jan 4.
5
Synthesis of a Coumarin-Based Analogue of Schweinfurthin F.合成一种新型香豆素类喜树碱类似物。
J Org Chem. 2021 Dec 3;86(23):16824-16833. doi: 10.1021/acs.joc.1c02046. Epub 2021 Oct 29.
6
Flavonoid and stilbene derivatives from Macaranga trichocarpa.大戟科植物三叶崖爬藤中的黄酮和二苯乙烯衍生物。
Fitoterapia. 2018 Apr;126:74-77. doi: 10.1016/j.fitote.2017.10.001. Epub 2017 Oct 3.
7
Bioassay-guided isolation and structure elucidation of cytotoxic stilbenes and flavonols from the leaves of Macaranga barteri.生物测定指导下的从 Macaranga barteri 叶中分离细胞毒stilbenes 和 flavonols 及其结构鉴定
Fitoterapia. 2019 Apr;134:151-157. doi: 10.1016/j.fitote.2019.02.019. Epub 2019 Feb 27.
8
Small molecule schweinfurthins selectively inhibit cancer cell proliferation and mTOR/AKT signaling by interfering with trans-Golgi-network trafficking.小分子施万费菌素通过干扰反式高尔基体网络运输来选择性抑制癌细胞增殖和mTOR/AKT信号传导。
Cancer Biol Ther. 2015;16(4):589-601. doi: 10.1080/15384047.2015.1019184. Epub 2015 Mar 2.
9
Cytotoxic geranyl stilbenes from Macaranga schweinfurthii.来自施氏血桐的细胞毒性香叶基芪类化合物。
J Nat Prod. 1998 Dec;61(12):1509-12. doi: 10.1021/np980208m.
10
Schweinfurthins: Lipid Modulators with Promising Anticancer Activity.施温富菌素：具有潜在抗癌活性的脂质调节剂。
Lipids. 2018 Aug;53(8):767-784. doi: 10.1002/lipd.12088. Epub 2018 Oct 17.

引用本文的文献

1
Therapeutic Potential of 5'-Methylschweinfurthin G in Merkel Cell Polyomavirus-Positive Merkel Cell Carcinoma.5'-甲基 Schweinfurthin G 在 Merkel 细胞多瘤病毒阳性 Merkel 细胞癌中的治疗潜力。
Viruses. 2022 Aug 23;14(9):1848. doi: 10.3390/v14091848.
2
Synthesis of a Coumarin-Based Analogue of Schweinfurthin F.合成一种新型香豆素类喜树碱类似物。
J Org Chem. 2021 Dec 3;86(23):16824-16833. doi: 10.1021/acs.joc.1c02046. Epub 2021 Oct 29.

本文引用的文献

1
Cytotoxic Prenylated Stilbenes Isolated from Macaranga tanarius.从 Macaranga tanarius 中分离得到的细胞毒性芪类化合物。
J Nat Prod. 2017 Oct 27;80(10):2684-2691. doi: 10.1021/acs.jnatprod.7b00409. Epub 2017 Oct 3.
2
Recent developments in natural product-based drug discovery for tuberculosis.基于天然产物的抗结核药物发现的最新进展。
Drug Discov Today. 2017 Mar;22(3):585-591. doi: 10.1016/j.drudis.2016.11.015. Epub 2016 Nov 24.
3
Role of Natural Stilbenes in the Prevention of Cancer.天然芪类化合物在癌症预防中的作用。
Oxid Med Cell Longev. 2016;2016:3128951. doi: 10.1155/2016/3128951. Epub 2015 Dec 21.
4
TRPA1 channels as targets for resveratrol and related stilbenoids.TRPA1通道作为白藜芦醇及相关芪类化合物的作用靶点。
Bioorg Med Chem Lett. 2016 Feb 1;26(3):899-902. doi: 10.1016/j.bmcl.2015.12.065. Epub 2015 Dec 19.
5
A New Golden Age of Natural Products Drug Discovery.天然产物药物发现的新黄金时代。
Cell. 2015 Dec 3;163(6):1297-300. doi: 10.1016/j.cell.2015.11.031.
6
Resveratrol and cancer: focus on in vivo evidence.白藜芦醇与癌症：关注体内证据。
Endocr Relat Cancer. 2014 May 6;21(3):R209-25. doi: 10.1530/ERC-13-0171. Print 2014 Jun.
7
Cytotoxic deoxybenzoins and diphenylethylenes from Arundina graminifolia.来源于竹叶兰的细胞毒脱氧安息香和二苯乙烯
J Nat Prod. 2013 Oct 25;76(10):1854-9. doi: 10.1021/np400379u. Epub 2013 Sep 24.
8
Tubulin-interactive stilbene derivatives as anticancer agents.作为抗癌剂的微管蛋白相互作用的二苯乙烯衍生物。
Cell Mol Biol Lett. 2013 Sep;18(3):368-97. doi: 10.2478/s11658-013-0094-z. Epub 2013 Jul 1.
9
Genesis and development of DPPH method of antioxidant assay.DPPH 法抗氧化活性测定方法的起源与发展。
J Food Sci Technol. 2011 Aug;48(4):412-22. doi: 10.1007/s13197-011-0251-1. Epub 2011 Feb 25.
10
Biological activity of piceatannol: leaving the shadow of resveratrol.皮考汀醇的生物活性：摆脱白藜芦醇的阴影。
Mutat Res. 2012 Jan-Mar;750(1):60-82. doi: 10.1016/j.mrrev.2011.11.001.