Swine and cattle enterotoxigenic Escherichia coli-mediated diarrhea. Development of therapies based on inhibition of bacteria-host interactions.

Enterotoxigenic Escherichia coli (ETEC) frequently occurs in diarrheal disease afflicting domestic animals. In this paper is summarized the research carried out over the last decade on the two important determinants of virulence that plays a role in the development of the infection, namely the colonizing ability of the small intestine mediated by specific fimbrial adhesins acting as lectins and the production of enterotoxins. Recent progress in knowledge of the phenomenon led to alternative strategies of prevention and cure of enteric infection. Since bacterial recognition of mucosa surface receptors in an initial event in colonization, several approaches based on the competitive inhibition of ETEC adhesion have been developed. This review examines the following approaches: competitive colonization with non pathogenic strains, design of adhesin or toxin vaccines, receptor analog therapy and methods for in vivo suppression of virulence factors.