抗甲胎蛋白-F(ab)'2与阿霉素偶联物对小鼠可移植性肿瘤的作用。
The effect of anti-AFP-F(ab)'2 and adriamycin conjugate on transplantable tumors in mice.
作者信息
Tang W X, Li P L, Zhang W Y, Li S B
机构信息
Institute of Liver Disease, Tongji Hospital, Tongji Medical University, Wuhan.
出版信息
J Tongji Med Univ. 1991;11(3):155-8. doi: 10.1007/BF02888127.
Efficacy of the conjugate anti-AFP-F(ab)'2 with adriamycin, anti-AFP-F(ab)'2-adr, against transplantable tumors was studied in mice. The results showed that LD50 of anti-AFP-F(ab)'2-adr in mice was 7.43 mg/kg and that anti-AFP-F(ab)'2-adr in a dose of 1/10-1/5 LD50 could inhibit the growth of transplanted hepatocellular carcinoma. In addition, anti-AFP-F(ab)'2-adr with local application of AFP could markedly inhibit the growth of transplanted Ehrlich ascites cancer. From the above it is suggested that anti-AFP-F(ab)'2-adr can be used to treat hepatic carcinoma with satisfactory results.
研究了偶联阿霉素的抗甲胎蛋白F(ab)'2（抗AFP-F(ab)'2-阿霉素）对小鼠可移植肿瘤的疗效。结果显示，抗AFP-F(ab)'2-阿霉素在小鼠中的半数致死量（LD50）为7.43毫克/千克，1/10 - 1/5 LD50剂量的抗AFP-F(ab)'2-阿霉素可抑制移植性肝癌的生长。此外，局部应用甲胎蛋白的抗AFP-F(ab)'2-阿霉素可显著抑制移植性艾氏腹水癌的生长。由此表明，抗AFP-F(ab)'2-阿霉素可用于治疗肝癌，效果良好。
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