An Min, Shin Jeong A, Lee Sang-Min, Yoon Tak, Park Weon Seo, Choi Joon Il, Kim Chang-Min
Center for Liver Cancer, National Cancer Center, Goyang Korea.
Korean J Hepatol. 2006 Dec;12(4):562-7.
We report herein a case of 72-year-old woman in whom liver metastasis of colon cancer was presented with a marked elevation of serum alpha-fetoprotein (AFP) level. She was transferred to our hospital for multiple liver masses found on ultrasonogram. Abdominal computed tomogram revealed multiple low-density masses in the liver and wall thickening of the hepatic flexure of colon. The serum AFP level was 10,718.8 ng/mL. Colonoscopic findings of ulcerofungating mass suggested liver metastasis from colon cancer. However, the possibility of combined hepatocellular carcinoma could not be ruled out due to serum AFP elevation. Both colon and liver biopsies revealed moderately differentiated tubular adenocarcinoma. Using an immunohistochemical staining, the adenocarcinoma in liver showed focal positive to AFP, but not in colon. This case represents a very rare case of colon cancer with a marked elevation of serum AFP.
我们在此报告一例72岁女性患者，其结肠癌肝转移时血清甲胎蛋白（AFP）水平显著升高。她因超声检查发现肝脏有多个肿块而转入我院。腹部计算机断层扫描显示肝脏有多个低密度肿块以及结肠肝曲壁增厚。血清AFP水平为10718.8 ng/mL。结肠镜检查发现溃疡性蕈伞状肿块提示结肠癌肝转移。然而，由于血清AFP升高，不能排除合并肝细胞癌的可能性。结肠和肝脏活检均显示为中分化管状腺癌。通过免疫组织化学染色，肝脏中的腺癌对AFP呈局灶阳性，而结肠中的腺癌则为阴性。该病例是血清AFP显著升高的非常罕见的结肠癌病例。
