TMPRSS2:ERG基因融合与观察等待队列中致命性前列腺癌相关。
TMPRSS2:ERG gene fusion associated with lethal prostate cancer in a watchful waiting cohort.
作者信息
Demichelis F, Fall K, Perner S, Andrén O, Schmidt F, Setlur S R, Hoshida Y, Mosquera J-M, Pawitan Y, Lee C, Adami H-O, Mucci L A, Kantoff P W, Andersson S-O, Chinnaiyan A M, Johansson J-E, Rubin M A
机构信息
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115-6110, USA.
出版信息
Oncogene. 2007 Jul 5;26(31):4596-9. doi: 10.1038/sj.onc.1210237. Epub 2007 Jan 22.
The identification of the TMPRSS2:ERG fusion in prostate cancer suggests that distinct molecular subtypes may define risk for disease progression. In surgical series, TMPRSS2:ERG fusion was identified in 50% of the tumors. Here, we report on a population-based cohort of men with localized prostate cancers followed by expectant (watchful waiting) therapy with 15% (17/111) TMPRSS2:ERG fusion. We identified a statistically significant association between TMPRSS2:ERG fusion and prostate cancer specific death (cumulative incidence ratio=2.7, P<0.01, 95% confidence interval=1.3-5.8). Quantitative reverse-transcription-polymerase chain reaction demonstrated high ets-related [corrected] gene (ERG) expression to be associated with TMPRSS2:ERG fusion (P<0.005). These data suggest that TMPRSS2:ERG fusion prostate cancers may have a more aggressive phenotype, possibly mediated through increased ERG expression.
前列腺癌中TMPRSS2:ERG融合基因的鉴定表明，不同的分子亚型可能决定疾病进展风险。在手术系列研究中，50%的肿瘤中鉴定出TMPRSS2:ERG融合基因。在此，我们报告了一组基于人群的局限性前列腺癌男性队列，这些患者接受了观察等待治疗，其中15%（17/111）存在TMPRSS2:ERG融合基因。我们发现TMPRSS2:ERG融合基因与前列腺癌特异性死亡之间存在统计学显著关联（累积发病率比=2.7，P<0.01，95%置信区间=1.3-5.8）。定量逆转录聚合酶链反应表明，高表达的ets相关[校正后]基因（ERG）与TMPRSS2:ERG融合基因相关（P<0.005）。这些数据表明，TMPRSS2:ERG融合基因阳性的前列腺癌可能具有更具侵袭性的表型，可能是通过增加ERG表达介导的。
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