一名32岁进行性痴呆男性体内β-淀粉样蛋白的显示。
Demonstration of amyloid beta-protein in a 32-year-old man with progressive dementia.
作者信息
Guiroy D C, Liberski P P, Alwasiak J, Papierz W, Gajdusek D C
机构信息
Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.
出版信息
Acta Neuropathol. 1991;82(6):523-6. doi: 10.1007/BF00293389.
We report the immunolocalization of extensive amyloid beta-protein in senile plaques, cerebrovascular amyloid deposits, neurofibrillary tangles and preamyloid in a 32-year-old man with progressive dementia not due to trisomy 21 or trauma. These amyloid deposits were non-reactive to antibodies directed against scrapie amyloid. Our data indicate that the presence of amyloid beta-protein is not limited to normal aging, Alzheimer's disease and related disorders but is also found in younger individuals with progressive dementia.
我们报告了在一名32岁进行性痴呆男性患者（非21三体或外伤所致）的老年斑、脑血管淀粉样沉积物、神经原纤维缠结和淀粉样前体中广泛存在β-淀粉样蛋白的免疫定位情况。这些淀粉样沉积物对针对羊瘙痒病淀粉样蛋白的抗体无反应。我们的数据表明，β-淀粉样蛋白的存在不仅限于正常衰老、阿尔茨海默病及相关疾病，在患有进行性痴呆的较年轻个体中也能发现。
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