Wisniewski T, Lalowski M, Bobik M, Russell M, Strosznajder J, Frangione B
Department of Neurology, New York University Medical Center, NY 10016, USA.
Biochem J. 1996 Jan 15;313 ( Pt 2)(Pt 2):575-80. doi: 10.1042/bj3130575.
In alzheimer's disease, amyloid beta (A beta) is deposited in senile plaques and amyloid angiopathy. Longer A beta peptides, which extend to residue 42 (A beta 42), have been suggested to be critical for the seeding of amyloid. Aged dogs develop cerebral vessel amyloid and parenchymal preamyloid lesions. Preamyloid in humans is related to senile plaques, whereas in dogs such progression is rare. We evaluated the composition of aged canine vessel amyloid and preamyloid both biochemically and immunohistochemically. The vessel amyloid extended mainly to residue 40 (A beta 40), while preamyloid contained a mixture of A beta 17-42 and A beta 42, with minimal A beta 40. Our results suggest other factors besides A beta 42 are important for neuritic plaque formation.
在阿尔茨海默病中，β淀粉样蛋白（Aβ）沉积于老年斑和淀粉样血管病中。较长的Aβ肽延伸至第42位氨基酸残基（Aβ42），被认为对淀粉样蛋白的种子形成至关重要。老龄犬会出现脑血管淀粉样变和实质淀粉样前体病变。人类的淀粉样前体与老年斑有关，而在犬类中这种进展很少见。我们通过生化和免疫组化方法评估了老龄犬血管淀粉样蛋白和淀粉样前体的组成。血管淀粉样蛋白主要延伸至第40位氨基酸残基（Aβ40），而淀粉样前体包含Aβ17 - 42和Aβ42的混合物，Aβ40含量极少。我们的结果表明，除Aβ42外，其他因素对神经炎性斑块的形成也很重要。
