使用临床MRI时颅内面积作为颅内体积替代指标的验证。
Validation of intracranial area as a surrogate measure of intracranial volume when using clinical MRI.
作者信息
Nandigam R N Kaveer, Chen Yu-Wei, Gurol Mahmut E, Rosand Jonathan, Greenberg Steven M, Smith Eric E
机构信息
Department of Neurology, Neurology Clinical Trials Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
出版信息
J Neuroimaging. 2007 Jan;17(1):74-7. doi: 10.1111/j.1552-6569.2006.00069.x.
BACKGROUND AND PURPOSE
We sought to determine whether mid-sagittal intracranial area (ICA) is a valid surrogate of intracranial volume (ICV) when using retrospective data with relatively thick (6-7 mm) sagittal slices.
METHODS
Data were retrospectively analyzed from 47 subjects who had two MRI scans taken at least nine months apart. Twenty-three subjects had manual segmentation of ICV on the T2-weighted sequence for comparison.
RESULTS
Intraclass correlation coefficient (ICC) for intraobserver, interobserver, and intraobserver scan-rescan comparisons were 0.96, 0.97 and 0.95. Pearson correlation coefficients between ICV and ICA, averaging the cumulative 1, 2, 3, and 4 most midline slices, were 0.89, 0.94, 0.93, and 0.95. There was a significant marginal increase in explained variance of ICV by measuring two, rather than one, slices (P= 0.001).
CONCLUSIONS
These data suggest that ICA, even measured without high-resolution imaging, is a reasonable substitute for ICV.
背景与目的
我们试图确定，在使用矢状位切片相对较厚（6 - 7毫米）的回顾性数据时，矢状位颅内面积（ICA）是否是颅内体积（ICV）的有效替代指标。
方法
对47名受试者的数据进行回顾性分析，这些受试者至少间隔九个月进行了两次磁共振成像扫描。23名受试者在T2加权序列上对ICV进行了手动分割以作比较。
结果
观察者内、观察者间以及观察者内扫描 - 再扫描比较的组内相关系数（ICC）分别为0.96、0.97和0.95。平均累积1、2、3和4个最中线切片时，ICV与ICA之间的Pearson相关系数分别为0.89、0.94、0.93和0.95。测量两片而非一片切片时，ICV的可解释方差有显著的边际增加（P = 0.001）。
结论
这些数据表明，即使在没有高分辨率成像的情况下测量，ICA也是ICV的合理替代指标。
Zotero 插件