Payeras M R, Sant'Ana Filho M, Lauxen I S, Barbachan J J D
Department of Oral Pathology, School of Dentistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
J Oral Pathol Med. 2007 Feb;36(2):99-104. doi: 10.1111/j.1600-0714.2007.00472.x.
The aim of this study was to evaluate the proliferation activity by means of the quantification of the argyrophilic nucleolar organizer regions (AgNORs) and the patterns of expression of the epidermal growth factor receptor (EGFR) in ameloblastomas.
The methods of evaluation included the H/E stain for the morphologic analysis, the silver impregnation technique for quantification of the AgNORs and the immunohistochemical stain with anti-EGFR antibody in 11 cases of ameloblastoma.
The results did not show a significant statistical difference as per quantification of the AgNORs. The expression of the EGFR on the epithelial islands of ameloblastoma was not uniform, and the location of the expression was also variable. The predominant expression was that of cytoplasm and the islands with an expression of membrane only were rare and generally smaller in size.
The tumor presents an irregular growth. Smaller islands are associated with a higher proliferation activity and therefore could be responsible for tumor infiltration.
本研究旨在通过对成釉细胞瘤中嗜银核仁组织区（AgNORs）进行定量分析以及对表皮生长因子受体（EGFR）的表达模式进行评估，以评价其增殖活性。
评估方法包括对11例成釉细胞瘤进行苏木精-伊红（H/E）染色以进行形态学分析、采用银浸染技术对AgNORs进行定量分析以及用抗EGFR抗体进行免疫组织化学染色。
根据AgNORs定量分析结果，未显示出显著的统计学差异。成釉细胞瘤上皮岛中EGFR的表达并不均匀，其表达位置也存在差异。主要表达为细胞质表达，仅膜表达的上皮岛很少见且通常尺寸较小。
肿瘤呈不规则生长。较小的上皮岛与较高的增殖活性相关，因此可能是肿瘤浸润的原因。
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