[化学修饰血红蛋白作为犬失血性休克模型中人工氧载体的研究]

[Study of chemically modified hemoglobin as an artificial oxygen carrier in the model of hemorrhagic shock in dogs].

作者信息

Selivanov E A, Kochetygov N I, Gerbut K A, Azhigirova M A, Viazova E P, Zeĭnalov A M, Bystrova I M, Molokovskaia E I

出版信息

Biull Eksp Biol Med. 1991 Aug;112(8):142-4.

Abstract

Hemodynamic and gas-transporting properties of the chemically modified hemoglobin solution have been studied on the model of hemorrhagic shock in dog. It has been shown that the polymerized hemoglobin solution exerts the hemodynamic action just as the plasma substitute "polyglucin" does. However, in contrast to the latter, polyhemoglobin circulating in the vascular bed for a prolonged period of time increases the blood oxygen capacity and oxygen delivery to tissues with the resultant increase in body total oxygen taking-up.

摘要

在犬失血性休克模型上研究了化学修饰血红蛋白溶液的血流动力学和气体运输特性。结果表明，聚合血红蛋白溶液与血浆代用品“聚葡萄糖”一样具有血流动力学作用。然而，与后者不同的是，长时间在血管床中循环的多聚血红蛋白会增加血液的氧容量和向组织的氧输送，从而使机体总的氧摄取量增加。