Nees J E, Hauser C J, Shippy C, State D, Shoemaker W C
Surgery. 1978 Jun;83(6):639-47.
We studied the time course and interactions of hemodynamic, oxygen transport, colloid osmotic pressure (COP), and blood volume responses to 500 ml of crystalline hemoglobin (Hgb), 500 ml of whole blood (WB), 1,000 ml of Ringer's lactate (RL), and 500 ml of plasma protein fraction (PPF) given in random order to 12 mongrel dogs subjected to hemorrhagic shock by the standard Wiggers' technique. In general, hemodynamic and oxygen transport responses were greater and more prolonged after the colloids than after RL. These responses were related to concomitant improvement in blood volume and COP. Of the colloids, Hgb appeared to produce somewhat greater hemodynamic and oxygen transport changes. This was particularly evidenced by comparison of these responses when each fluid was the first agent used after the hemorrhage. By virtue of its capacity to increase COP and plasma volume and to carry oxygen, Hgb improved both the gross circulation and the tissue perfusion, as indicated by cardiovascular hemodynamics and bulk oxygen transport variables.
我们采用标准的维格斯技术，使12只杂种犬遭受失血性休克，然后以随机顺序给它们输注500毫升结晶血红蛋白（Hgb）、500毫升全血（WB）、1000毫升乳酸林格液（RL）和500毫升血浆蛋白组分（PPF），研究了血流动力学、氧输送、胶体渗透压（COP）和血容量对这些输注的时间过程及相互作用。一般来说，胶体输注后血流动力学和氧输送反应比RL输注后更大且更持久。这些反应与血容量和COP的相应改善有关。在胶体中，Hgb似乎能产生稍大的血流动力学和氧输送变化。当每种液体作为出血后首次使用的药物时，比较这些反应可特别证明这一点。凭借其增加COP和血浆容量以及携带氧气的能力，Hgb改善了体循环和组织灌注，心血管血流动力学和大量氧输送变量表明了这一点。
