Matsumoto Yuka, Yamamoto Toshiyuki, Isobe Tamaki, Kusunoki Toshio, Tsuboi Ryoji
Department of Dermatology, Tokyo Medical University, Tokyo, Japan.
J Dermatol. 2007 Feb;34(2):114-6. doi: 10.1111/j.1346-8138.2006.00228.x.
Lichen sclerosus is a chronic inflammatory skin disorder that has a predilection for the anogenital area. Topical corticosteroid is occasionally effective; however, continuous treatment is often required and recurrence after its stoppage is frequent. Herein, we report a case of vulvar lichen sclerosus in a 5-year-old girl, which was refractory to topical corticosteroids. After 14 weeks of treatment with 0.03% tacrolimus ointment once daily, the lesions completely resolved without side-effects. Of interest, the number of milia within the plaque of lichen sclerosus was reduced in tandem with the improvement of lichen sclerosus. This is the first report of topical low-concentration tacrolimus treatment showing a dramatic effect in the treatment of childhood vulvar lichen sclerosus.
硬化性苔藓是一种慢性炎症性皮肤病，好发于肛门生殖器部位。外用糖皮质激素偶尔有效；然而，通常需要持续治疗，停药后复发很常见。在此，我们报告一例5岁女童外阴硬化性苔藓，外用糖皮质激素治疗无效。每日一次外用0.03%他克莫司软膏治疗14周后，皮损完全消退且无副作用。有趣的是，硬化性苔藓斑块内的粟丘疹数量随着硬化性苔藓的改善而减少。这是首次报道外用低浓度他克莫司治疗儿童外阴硬化性苔藓有显著疗效。
